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1421 deaths

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Mehmed I
fifth Ottoman Sultan (1413–1421)
Khizr Khan
25th Sultan of the Delhi Sultanate and 1st from the Sayyid dynasty
Jean Le Maingre
Marshal of France (1366-1421)
Nanni di Banco
Italian artist (1380-1421)
Thomas of Lancaster, 1st Duke of Clarence
Prince of England
Shaykh al-Mahmudi
Sultan of Egypt and Syria (r. 1412–1421)
Sayf ad-Din Tatar
Mamluk sultan
Philibert de Naillac
Grand Master of the Knights Hospitaller
Bayezid Pasha
Albanian grand Vizier
Balša III
Serbian noble (1387-1421)
Angelo Tartaglia
condottiero
Jan Kropidło
Polish prince-archbishop
Henry III, Count of Schauenburg-Holstein
Count of Holstein and Bishop of Osnabrück
Balthasar of Werle
Lord of Werle-Güstrow, Prince of the Wends
Helvis of Brunswick-Grubenhagen
Queen Consort of Cyprus and Titular Queen Consort of Armenia and Jerusalem
Shō Shishō
, or in later sources, was Anji of Sashiki and later King of Chūzan, one of three polities on the island of Okinawa, before they were united. He was the progenitor of what became the First Shō dynasty.
Razadarit
Razadarit (, ; , or ; also spelled Yazadarit, "king of kings"; 1368–1421), personal name Pasoom-Paing-Cek ( ; ), courtesy name Benya Noy (, ; , ), was king of Hanthawaddy Pegu from 1384 to 1421. He successfully unified his Mon-speaking kingdom, and fended off major assaults by the Burmese-speaking Ava Kingdom (Inwa) in the Forty Years' War. The king also instituted an administrative system that left his successors with a far more integrated kingdom. He is one of the most famous kings in Burmese history.
Thomas de Camoys, 1st Baron Camoys
English peer
Lakha Singh
maharana
Hermann of Cilli
Bishop of Freising; nominated Prince-Bishop of Trent
John FitzAlan, 13th Earl of Arundel
English noble
Sultan Awais Jalayir
Ruler of Basra
Frederick I, Duke of Brunswick-Osterode
Duke of Brunswick-Osterode
Grand Prince Hoean
son of Taejo of Joseon
Minkhaung I
Burmese monarch
Alfons de Tous
Spanish bishop
Person Gobelinus
German historian
Oldřich Vavák of Hradec
Bohemian nobleman and mintmaster (died 1421)