1521 births

pope of the Catholic Church from 1585 to 1590

pope of the Catholic Church in September 1590

Japanese daimyo of the Sengoku period

Dutch, Jesuit priest, Doctor of the Church, Roman Catholic saint

duchess consort of Milan and duchess consort of Lorraine (1521-1590)

Ottoman prince, son of Suleiman the Magnificent and Hürrem Sultan Magnificent

Duke of Saxony and later Elector of Saxony (1521–1553)

Sicilian Theatine priest and saint

Portuguese infanta (1521-1577)

English rebel leader during the reign of Queen Mary I (1521-1554)

English Protestant martyr

French painter (1521-1599)

Ming Dynasty painter (1521-1593)

Flemish musician and composer

Italian military engineer (1521-1570)

Duke of Saxe-Coburg (1521-1553)

Italian scholar, humanist and man of letters (1521-1586)

Ruler of Moldavia

Count Palatine of Simmern

Italian historian (1521-1589)

French general (1521-1569)

duke of Schleswig-Holstein-Haderslev

Italian Mannerist painter (1521–1575)

samurai

daimyo

Ruling Count of Solms-Laubach

Italian cardinal (1522-1586)

French magistrat (1521-1559)

Italian cardinal

politician

Italian cardinal

French writer

Italian architect

German theologian

Archbishop and Cardinal

Croatian writer and translator

Baraminreachea (, ; 1521–1576) was the Cambodian king who reigned from 1566 to 1576.

Portuguese cartographer (1521–1576)

leader of a peasant rebellion in Hwanghae Province, Korea

noblewoman; wife of Japanese daimyo Takeda Shingen

daimyo

Italian painter (1522-1593)

Burgrave of Thouars, raised to Duke of Thouars

French military personnel

Bishop of London

Dutch classical scholar

Belgian theologist

German theologian (1521-1600)

German composer and luth player

Polish noble

Reformed Theologian

Dominican friar from Florence, writer, poet, and translator

painter from the Southern Netherlands (1521–1574)

Italian grammarian

Japanese martial artist

Italian painter (1521-1601)

Dutch merchant, banker and shipbuilder (1521–1581)