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1581 deaths

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Mahidevran Hatun
Mahidevran Hatun (; – 3 February 1581) also known as Gülbahar Hatun, (, meaning "spring rose"), was a concubine of Sultan Suleiman the Magnificent of the Ottoman Empire and the mother of Şehzade Mustafa.
Guru Ram Das
The fourth Guru of Sikhism
Bayinnaung
Bayinnaung Kyawhtin Nawrahta; 16 January 1516 – 10 October 1581), personal name Maung Yeh Htut (ရှင်ရဲထွတ်), was King of Burma from 30 April 1550 until his death in 1581, during the Toungoo dynasty. His reign is considered one of the most momentous in Burmese history, famously described as "the greatest explosion of human energy ever seen in Burma". During his rule, he assembled the largest empire in Southeast Asian history, which encompassed much of present-day Myanmar, as well as the Shan States, Lan Na, Lan Xang, Manipur, and the Ayutthaya Kingdom.
Edmund Campion
English Jesuit priest, martyr and saint
Archduchess Maria of Austria
daughter of Emperor Ferdinand I from the House of Habsburg and Anna Jagiello (1531–1581)
Tsarevich Ivan Ivanovich of Russia
16th century Russian tsarevich
Guillaume Postel
French linguist, astronomer, diplomat and professor (1510–1581)
Christopher Báthory
voivode of Transylvania
Francis I, Duke of Saxe-Lauenburg
German duke
Honoré I, Lord of Monaco
Lord of Monaco (1522-1581)
Louis Bertrand
Spanish Dominican missionary and saint
Duchess Sabine of Württemberg
Princess of Württemberg by birth, and by marriage, Landgravine of Hesse-Kassel (1549-1581)
Frans Pourbus the Elder
Flemish painter (1545–1581)
Jean de la Cassière
Grand Master of the Knights Hospitaller
Mathurin Romegas
Grand Master of the Knights Hospitaller
James Douglas, 4th Earl of Morton
Regent of Scotland
Francisco de Aguirre
Spanish conquistador
Saiful Rijal of Brunei
Sultan of Brunei
Hubert Languet
French diplomat and polemist (1518-1581)
Pedro Chacón
Spanish mathematician and theologian
Jakub Uchański
Archbishop of Poland
Alessandro Sforza
Italian Roman Catholic bishop and cardinal
Andreas Musculus
German theologian
Peder Skram
Danish admiral
Antoine de Bertrand
French composer of the Renaissance
Prospero Centurione Fattinanti
politician
Alexander Briant
Jesuit martyr
Odet de Turnèbe
French dramatist
Ralph Sherwin
English Roman Catholic martyr and saint (1550-1581)
George van Lalaing
Dutch stadtholder (1536-1581)
Joos de Damhouder
Belgian jurist
Flavio Orsini
Catholic cardinal
Achilles Statius
Portuguese humanist
Johann Marbach
German theologian
Bartolomé de Medina
Spanish theologian
Justus Velsius
Dutch humanist
Nicholas Sanders
British priest
Okabe Motonobu
samurai
Willem de Pannemaker
tapestry maker from the Southern Netherlands (1512–1581)
Fernão de Oliveira
Priest and grammarian
Peter Nirsch
German serial killer
Sagara Yoshiharu
Daimyo who ruled a region in southern Higo Province
Qvarqvaré VI Jakéli
atabeg of Samtskhe
Thomas Wilson
English diplomat, judge, and privy councillor in the government of Elizabeth I (1524-1581)
Johannes Gigas
German theologian and writer (1514-1581)
Alexander Utendal
Flemish composer
Chandrasen Rathore
ruler of Marwar
Georgette de Montenay
French writer
Mayadunne of Sitawaka
Sri Lankan King
Marcellus Coffermans
Flemish painter, active 1549-1575 (1524–1581)
Agatha Streicher
German physician (1520–1581)
Karaliyadde Bandara of Kandy
king of Kandy
Jacques de Billy
French abbot
Michael Neander
German astronomer (1529-1581)
Anthony, Metropolitan of Moscow
Metropolitan of Moscow
Richard Cox
Bishop of Ely
Kyōgoku Takayoshi
daimyo of the Sengoku period
Mae Ku
King of Lan Na
Francisco Foreiro
Portuguese Dominican theologian
Mirza Shukr Allah Isfahani
16th-century Persian statesman