15th-century monarchs in North America

Itzcoatl ( , "Obsidian Serpent", ) (c. 1380–1440) was the fourth king of Tenochtitlan, and the founder of the Aztec Empire, ruling from 1427 to 1440. Under Itzcoatl the Mexica of Tenochtitlan threw off the domination of the Tepanecs and established the Triple Alliance (Aztec Empire) together with the other city-states Tetzcoco and Tlacopan.

250px|thumb|Map showing the expansion of the Aztec Triple Alliance. The conquests of Ahuitzotl are marked in yellow.

thumb|500px|Map showing territorial expansions of the Aztec Empire under each of the Aztec rulers. Expansions during the reign of Axayacatl are indicated in blue.

Tizocic (), or Tizocicatzin (), usually known in English as Tizoc, was the seventh tlatoani of Tenochtitlan. His name means, "He who makes sacrifices" or "He who does penance." Either Tizoc or his successor Ahuitzotl was the first tlatoani of Tenochtitlan to assume the title Huey Tlatoani ("supreme tlatoani") to make their superiority over the other cities in the Triple Alliance (Aztec Empire) clear.

Chimalpopoca ( for "smoking shield," ) or Chīmalpopōcatzin (1397–1427) was the third Emperor of Tenochtitlan (1417–1427).

Huitzilihuitl () or Huitzilihuitzin (Nahuatl language; English: Hummingbird Feather) (1370s – ca. 1417) was the second Tlatoani or king of Tenochtitlan. According to the Codex Chimalpahin, he reigned from 1390 to 1415, according to the Codex Aubin, he reigned from 1396 to 1417 and according to the Codex Chimalpopoca, he reigned from 1403 to 1417.

Ruler of Azcapotzalco (1320-1426)

Guacanagarix (alternate transcriptions: Guacanacaríc, Guacanagarí) was one of five Taíno caciques of the Caribbean island henceforth known as Hispaniola at the arrival of the Europeans in 1492. This was contemporaneous with the first of the voyages of Christopher Columbus.

Ruler of the Acolhua city-state of Texcoco

Caonabo (died 1496) was a Taíno cacique (chieftain) of Hispaniola at the time of Christopher Columbus's arrival to the island. Was known for his fighting skills and his ferocity. He was married to Anacaona, who was the sister of another cacique named Bohechío.

Tlacateotl (or Tlacateotzin; ? – 1426 or 1427/28) was the second Tlatoani of the Aztec city of Tlatelolco from 1417 until his death.

Quaquapitzahuac (died 1417) was the first ruler of the Aztec city of Tlatelolco. His name, which means "Slender Horn", was pronounced in Classical Nahuatl, and is also spelled Cuacuauhpitzahuac, Cuacuapitzahuac, and Quaquauhpitzahuac.