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1646 deaths

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Maria Anna of Spain
Wife of Holy Roman Emperor Ferdinand III (1606-1646)
Balthasar Charles
Prince of Asturias; (1629-1646)
Odoardo Farnese
Duke of Parma and Piacenza from 1622 to 1646
Henri, Prince of Condé
French prince
William Dobson
English portrait painter (1610-1646)
Stanisław Koniecpolski
Polish nobleman (1591-1646)
Francesco Erizzo
Doge of Venice (1566-1646)
Zhu Yousong, Prince of Fu
Southern Ming Emperor from 1644 to 1645
Margherita Aldobrandini
Noblewoman (1588-1646)
Maria Caterina Farnese
Duchess of Modena and Reggio
Zhu Yujian
Chinese emperor (1602-1646)
Antonio Marcello Barberini
Italian cardinal
Hosokawa Tadaoki
daimyo
Thomas Howard, 21st Earl of Arundel
English diplomat (1585-1646)
Yagyū Munenori
samurai and daimyo of the early Edo period (1571-1646)
Robert Devereux, 3rd Earl of Essex
English noble and parliamentarian general
François de Bassompierre
French courtier and Marshal of France (1579-1646)
Francesco Furini
Italian painter, poet and priest (1603–1646)
Isaac Jogues
Beatified Martyred Jesuit Priest
Duarte Lobo
Portuguese composer
Elias Holl
German architect (1573–1646)
Jakub Sobieski
Polish noble
Parthenius I of Constantinople
Ecumenical Patriarch of Constantinople in 1639–1644
Martin Vries
Dutch explorer of Japan (1589–1647)
Sultanzade Mehmet Paşa
Ottoman grand vizier (1603–1646)
François Maynard
French writer
Oliva Sabuco
Spanish philosopher (1562-1646)
Virgilio Mazzocchi
Italian Baroque composer
Louis Günther I, Count of Schwarzburg-Rudolstadt
Count of Schwarzburg-Rudolstadt
Johannes Rudbeckius
Swedish bishop
Michelangelo Buonarroti
Italian writer
Sophie of Brandenburg-Ansbach
(1614-1646)
Jean Armand de Maillé-Brézé
French admiral (1619-1646)
Opechancanough
thumb|A 1585 painting of a Chesapeake Bay warrior by John White; this painting was adapted to represent Opechancanough in the engraving above.
Johann Vierdanck
German composer and musician
María Calderón
Spanish royal mistress
Jean de Lalande
Jesuit lay missionary
Nicolas Faret
French writer (1600-1646)
Lady Ann Cunningham
Scottish noblewoman
Melpathur Narayana Bhattathiri
Indian mathematician
Pieter van den Keere
Dutch engraver (1571–1646)
Santino Solari
Italian architect (1576-1646)
Henry Somerset, 1st Marquess of Worcester
Marquess of Worcester
Manuel de Almeida
Christian missionary
Adriaan van der Stel
Dutch governor of Mauritius from 1640 to 1645
Daniel Dumonstier
French artist (1574-1646)
Jean François Niceron
French cleric and mathematician (1613–1646)
Alexander Henderson
Minister of the Church of Scotland, theologian; (1583-1646)
Tomasz Sapieha
Polish-Lithuanian noble
Fulvio Testi
Italian diplomat (1593-1646)
Huang Daozhou
Chinese calligrapher (1585-1646)
Laurentius Paulinus Gothus
Swedish astronomer and archbishop (1565-1646)
Erycius Puteanus
humanist, philologist (1574–1646)
Constantino Tencalla
Swiss architect and sculptor
Gaspard III de Coligny
Marshal of France (1584-1646)
Pope Matthew III of Alexandria
Pope of Alexandria
Álvaro de Bazán, 2nd Marquis of Santa Cruz
Second Marquis of Santa Cruz
Giandomenico Spinola
Italian archbishop and cardinal
Johannes Polyander
Dutch theologian (1568-1646)
Date Shigezane
samurai