2000 in the United States

22nd census, which determined the resident population of the United States on April 1, 2000

STS-101 was a Space Shuttle mission to the International Space Station (ISS) flown by Space Shuttle Atlantis. The mission was a 10-day mission conducted between 19 May 2000 and 29 May 2000. The mission was designated 2A.2a and was a resupply mission to the International Space Station. STS-101 was delayed 3 times in April due to high winds. STS-101 traveled 4.1 million miles and completed 155 revolutions of the earth and landed on runway 15 at Kennedy Space Center. The mission was the first to be flown by a shuttle equipped with a glass cockpit.

STS-106 was a 2000 Space Shuttle mission to the International Space Station (ISS) flown by Space Shuttle Atlantis.

STS-92 was a Space Shuttle mission to the International Space Station (ISS) flown by Space Shuttle Discovery. STS-92 marked the 100th mission of the Space Shuttle and Discovery's 28th flight. It was launched from Kennedy Space Center, Florida, 11 October 2000.

STS-99 was a Space Shuttle mission using Endeavour, that launched on 11 February 2000 from Kennedy Space Center, Florida. The primary objective of the mission was the Shuttle Radar Topography Mission (SRTM) project. This was also the last solo flight of Endeavour; all future flights for Endeavour became devoted to the International Space Station. STS-99 was also the first Shuttle mission of the 2000s.

overview of USA-related events during the year of 2000