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2D animation software

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Adobe Animate
interactive multimedia content authoring app
Vyond
GoAnimate, Inc., doing business as Vyond since 2018, is an American privately held software company based in San Mateo, California. Founded in 2007 by Alvin Hung, the company operates a cloud-based video creation platform oriented towards businesses and enterprises, including an animated video maker known as Vyond Studio, the company's flagship and most-well-known product and an evolution of the company's original Flash-based video maker, and an AI-powered instant video maker known as Vyond Go.
Synfig
Synfig Studio (also known as Synfig) is a free and open-source vector-based 2D animation software. It is created by Robert Quattlebaum with additional contributions by Adrian Bentley.
Toon Boom Animation
Canadian software company
Pencil2D
Pencil2D is a free and open-source 2D animation software for Windows, macOS, and Unix-like operating systems. It is released under the GNU General Public License and uses the Qt framework. It is used for making cartoons using traditional techniques (tracing drawings, onion skinning, etc), managing vector and bitmap drawings.
Clip Studio Paint
digital illustration software
Moho
2D animation software
TVPaint
animation software package by TVPaint Developpement
Flipnote Studio
application for the Nintendo DSi
Flipnote Studio 3D
application for the Nintendo 3DS
Live2D
Live2D is an animation technique (not to be mistaken with software used to create Live2D animation such as Live2D Cubism) used to animate static images—usually anime-style characters—that involves separating an image into parts and animating each part accordingly, without the need of frame-by-frame animation or a 3D model. This enables characters to move using 2.5D movement while maintaining the original illustration.
SWiSH Max
software used to create cross-platform presentations
Adobe Character Animator
motion-capture software
The Simpsons: Cartoon Studio
1996 video game
Autodesk Animator
software
Tiny Toon Adventures Cartoon Workshop
1992 video game