4th-century regents

Domnica was a Roman empress as the wife of the emperor Valens, who ruled the East from 364 to 378. After the death of her husband at the Battle of Adrianople, she ruled as de facto regent and defended Constantinople against the attacking Goths until his successor Theodosius I arrived.

Parandzem (; died winter 369/70) was the consort of King Arshak II of Armenia. She was a member of the noble house of Siuni. She was regent of Armenia during the absence of her spouse and son in 368–370, and is famous for her defense of the fortress of Artagers against Persia. She was brutally put to death by the Persians after the fall of Artagers in the winter of 369/70. Her son Pap was soon after restored to the throne with Roman assistance.

Prince of Zhao and Jin dynasty usurper (died 301)

Prabhavatigupta (died ) was a Gupta princess and Vakataka queen who was the consort of Maharaja Rudrasena II. Following the death of her husband, she effectively ruled the Vakataka Empire as regent from about 390 to 410.

Imperial prince and regent

Jin Dynasty empress

Jin dynasty imperial prince (died 306)

Jin Dynasty Prince of Qi (died 302)

Jin Dynasty imperial prince

thumb|Zarmanduxt.jpg124 Zarmandukht (also spelled Zarmanduxt; fl. 383) was the consort of King Pap of Arsacid Armenia, who ruled from 370 to 374. She was regent of Armenia during the minority of her sons, co-rulers Arsaces (Arshak) III and Vologases (Vagharshak) II, who ruled from 378 to 386/387.

Persian noblewoman

Imperial prince, regent, crown prince and general (279-306)

wife of Shi Hu, emperor of Later Zhao

Chinese empress