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American lead guitarists

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Jimi Hendrix
American guitarist (1942–1970)
Kurt Cobain
Kurt Donald Cobain was an American musician. He was the lead vocalist, guitarist, primary songwriter, and a founding member of the grunge band Nirvana. Through his angsty songwriting and anti-establishment persona, he widened the thematic conventions of mainstream rock music. He was heralded as a spokesman of Generation X, and is widely recognized as one of the most influential rock musicians.
Prince (musician)
Prince Rogers Nelson, known mononymously as Prince, was an American singer, songwriter, musician, dancer, actor, and filmmaker. Often being credited as one of the greatest musicians of his generation, he pioneered the Minneapolis sound and was influential in the evolution of various other genres.
Frank Zappa
American musician (1940–1993)
Bruce Springsteen
Bruce Frederick Joseph Springsteen is an American singer, songwriter, and musician. Nicknamed "the Boss", Springsteen has released 21 studio albums spanning six decades; most of his albums feature the E Street Band, his backing band since 1972.
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American blues guitarist, singer, and songwriter (1925–2015)
Chuck Berry
American musician (1926–2017)
Lou Reed
American rock musician (1942–2013)
Neil Young
Neil Percival Young is a Canadian and American singer-songwriter. Son of journalist and author Scott Young, Young embarked on a music career in Winnipeg in the 1960s. He then moved to Los Angeles, forming the folk rock group Buffalo Springfield. His solo career, often backed by the band Crazy Horse, includes critically acclaimed albums such as Everybody Knows This Is Nowhere (1969), After the Gold Rush (1970), Harvest (1972), On the Beach (1974), and Rust Never Sleeps (1979). Young was also a part-time member of Crosby, Stills, Nash & Young, with whom he recorded the chart-topping 1970 album Déjà Vu.
Buddy Holly
American rock and roll singer (1936–1959)
Carlos Santana
American guitarist
Lenny Kravitz
American rock musician
Billie Joe Armstrong
Billie Joe Armstrong is an American musician and actor. He is best known for being the lead vocalist, guitarist, and primary songwriter of the rock band Green Day, which he co-founded with Mike Dirnt in 1987. He is also a guitarist and vocalist for the punk rock band Pinhead Gunpowder, and provides lead vocals for Green Day's side projects Foxboro Hot Tubs, the Network, the Longshot and the Coverups. Armstrong has been considered by critics as one of the greatest punk rock guitarists of all time, as well as one of the greatest punk rock singers of all time.
Slash
British musician
Dave Mustaine
American musician
Kirk Hammett
American guitarist
Eddie Van Halen
Dutch-American rock guitarist (1955–2020)
Muddy Waters
American blues musician (1913–1983)
Stevie Ray Vaughan
American blues guitarist (1954–1990)
Joe Satriani
American guitarist
John Frusciante
American guitarist
Steve Vai
American guitarist
Ike Turner
American musician (1931–2007)
Jack White
John Anthony White is an American musician and record producer who was the guitarist and lead vocalist of the rock duo the White Stripes. He was a key artist of the 2000s indie and garage rock movements, noted for his distinctive musical techniques, eccentricity, and utilization of analog technology. After the White Stripes split up in 2011, he found success with his solo career and business ventures.
Brad Delson
American guitarist and rock musician
David Byrne
Scottish-American musician (born 1952)
George Benson
American guitarist and singer (born 1943)
Tyler Posey
American actor, musician (b. 1991)
John Petrucci
American guitarist (born 1967)
Tom Morello
American guitarist and musician
Glen Campbell
American musician (1936–2017)
Joey Jordison
American musician (1975–2021)
Joe Perry
American musician (born 1950)
Carl Perkins
American guitarist
Chuck Schuldiner
American musician (1967–2001)
Richie Sambora
American rock musician
Steve Morse
American guitarist
Jerry Garcia
American guitarist and singer (1942–1995)
Kerry King
American guitarist (born 1964)
Jeff Hanneman
American guitarist (1964–2013)
John Fogerty
American musician (born 1945)
Buddy Guy
American blues guitarist and singer
Pat Metheny
American jazz musician
Randy Rhoads
American guitarist (1956–1982)
Dick Dale
American surf rock guitarist (1937–2019)
Dimebag Darrell
American guitarist (1966–2004)
Synyster Gates
American guitarist
Marty Friedman
American guitarist
Ry Cooder
American guitarist, singer and composer
Billy Corgan
American musician
Duane Allman
American guitarist (1946–1971)
Robby Krieger
American guitarist
Brad Paisley
American country musician (born 1972)
Ace Frehley
Paul Daniel "Ace" Frehley was an American musician who was the original lead guitarist, occasional vocalist, and a founding member of the rock band Kiss. He invented the persona of the Spaceman and originally played with the group from its inception in 1973 until his departure in 1982, before later rejoining in 1996 until his final departure in 2002.
Johnny Ramone
American guitarist (1948–2004)
Johnny Winter
American blues guitarist and singer (1944–2014)
Buckethead
Al Di Meola
American guitarist
Hillel Slovak
Hillel Slovak was an Israeli-American musician, best known as an early guitarist of the Los Angeles rock band the Red Hot Chili Peppers, with whom he recorded two albums. His guitar work was rooted in funk and hard rock, and he often experimented with other genres, including reggae and speed metal. He is considered to have been a major influence on the Red Hot Chili Peppers' early sound.
Sterling Morrison
American musician (1942–1995)