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American multi-instrumentalists

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Michael Jackson
Michael Joseph Jackson was an American singer, songwriter, dancer, and philanthropist. Dubbed the "King of Pop", he is widely regarded as one of the most culturally significant figures of the 20th century. Over a four-decade career, his musical achievements broke American racial barriers and made him a dominant figure worldwide. Through his songs, concerts, and fashion, he proliferated visual performance for artists in popular music, popularizing street dance moves such as the moonwalk, the robot, and the anti-gravity lean. Jackson is often deemed the greatest entertainer of all time.
Bob Dylan
Bob Dylan is an American singer-songwriter. Described as one of the greatest songwriters of all time, Dylan has been a major figure in popular culture over his 69-year career. With an estimated 125 million records sold worldwide, he is one of the best-selling musicians. Dylan added increasingly sophisticated lyrical techniques to the folk music of the early 1960s, infusing it "with the intellectualism of classic literature and poetry". His lyrics incorporated political, social, and philosophical influences, defying pop music conventions and appealing to the burgeoning counterculture.
Frank Zappa
American musician (1940–1993)
Prince (musician)
Prince Rogers Nelson, known mononymously as Prince, was an American singer, songwriter, musician, dancer, actor, and filmmaker. Often being credited as one of the greatest musicians of his generation, he pioneered the Minneapolis sound and was influential in the evolution of various other genres.
Bruce Springsteen
Bruce Frederick Joseph Springsteen is an American singer, songwriter, and musician. Nicknamed "the Boss", Springsteen has released 21 studio albums spanning six decades; most of his albums feature the E Street Band, his backing band since 1972.
Stevie Wonder
American and Ghanaian singer-songwriter, composer and record producer (born 1950)
Jared Leto
Jared Joseph Leto is an American actor and musician. Known for his method acting in a variety of roles, he has received numerous accolades over a career spanning three decades, including an Academy Award and a Golden Globe Award. Additionally, he is recognized for his musicianship and eccentric stage persona as frontman of the rock band Thirty Seconds to Mars.
Dave Grohl
American rock musician
Quincy Jones
American record producer and composer (1933–2024)
Lenny Kravitz
American rock musician
Billy Joel
American singer, songwriter, and pianist (born 1949)
Moby
Richard Melville Hall (born September 11, 1965), known professionally as Moby, is an American musician, songwriter and animal rights activist. He has sold 20 million records worldwide. AllMusic considers him to be "among the most important dance music figures of the early 1990s, helping bring dance music to a mainstream audience both in the United States and the United Kingdom".
Tom Waits
American singer-songwriter and actor (born 1949)
Jerry Lee Lewis
American rock 'n' roll musician (1935–2022)
Serj Tankian
Armenian-American musician
Linda Ronstadt
American singer (born 1946)
John Carpenter
American filmmaker, composer and actor (born 1948)
John Legend
American singer-songwriter
Tom Petty
American musician
Beck
Beck David Hansen (born Bek David Campbell; July 8, 1970), known mononymously as Beck, is an American singer, songwriter, and record producer. He rose to fame in the early 1990s with his experimental and lo-fi style, and became known for creating musical collages of wide-ranging genres. He has musically encompassed folk, funk, soul, hip hop, electronica, alternative rock, country, and psychedelia. He has released 15 studio albums, as well as several non-album singles and a book of sheet music.
Darren Criss
American actor and singer
David Byrne
Scottish-American musician (born 1952)
Jason Newsted
American musician
Trent Reznor
American musician, singer, songwriter, record producer and composer
Captain Beefheart
American musician and painter (1941-2010)
Duff McKagan
American rock musician
Joey Jordison
American musician (1975–2021)
Don Henley
American rock musician
John Stamos
American actor
Jaron Lanier
American computer scientist, musician, and author
Kid Rock
Robert James Ritchie, known professionally as Kid Rock, is an American musician, singer, rapper, and songwriter. After establishing himself in the Detroit hip-hop scene, he broke through into mainstream success with a rap rock sound before shifting his performance style to country rock. A self-taught musician, he can play every instrument in his backing band and has overseen production on all but two of his albums.
Ry Cooder
American guitarist, singer and composer
Izzy Stradlin
American rock guitarist
Sly Stone
American musician, singer, guitarist, and record producer (1943–2025)
Buckethead
Shannon Leto
American drummer
Jordan Rudess
American keyboardist
Mark Salling
American actor and musician (1982–2018)
Joe Walsh
American rock musician
Rob Thomas
American singer (born 1972)
Kris Allen
American musician and singer-songwriter
Jackie Jackson
Sigmund Esco "Jackie" Jackson is an American singer and songwriter. He is a founding member and the sole constant member of the Jackson 5, for which he was inducted into the Rock and Roll Hall of Fame in 1997. He is the second child of the Jackson family, and the oldest Jackson brother.
Ben Harper
American singer-songwriter and musician
Josh Klinghoffer
American musician
Marlon Jackson
Marlon David Jackson is an American singer and dancer best known as a member of the Jackson 5. He is the sixth child of the Jackson family. Marlon now runs Study Peace Foundation to promote peace and unity worldwide.
Keith Urban
Keith Lionel Urban is an Australian and American country singer, songwriter and guitarist. Recognised with four Grammy Awards, he has also received 15 Academy of Country Music Awards, including the Jim Reeves International Award, 13 CMA Awards, and six ARIA Music Awards. Urban wrote and performed the song "For You" from the film Act of Valor, which earned him nominations at both the 70th Golden Globe Awards and at the 18th Critics' Choice Awards in the respective Best Original Song categories.
Lindsey Buckingham
American musician
Stephen Stills
American musician (born 1945)
Kathleen Hanna
American musician and feminist activist
Randy Jackson (Jacksons singer)
Steven Randall Jackson is an American musician, singer, songwriter, and dancer. He is the ninth child in the Jackson family. Randy is the youngest Jackson brother and the second-youngest Jackson sibling before his sister Janet. Randy is a former member of his family band the Jacksons, which he joined after his brother Jermaine left the group. He was nominated for a Grammy Award for his work on the 1980 studio album Triumph.
Leon Russell
American singer-songwriter, guitarist, pianist and session musician
Ty Dolla Sign
American singer and rapper (born 1982)
La Monte Young
American avant-garde composer (born 1935)
Marcus Miller
American musician, composer and producer
Blackie Lawless
American heavy metal musician
Josh Homme
American musician
Levon Helm
American musician (1940–2012)
Tim McIlrath
American rock musician
Omar Rodríguez-López
American musician and record producer
Bill Mumy
American actor