Antifungals

Thujaplicin (isopropyl cycloheptatrienolone) is any of three isomeric tropolone-related natural products that have been isolated from the softwoods of the trees of Cupressaceae family. These compounds are known for their antibacterial, antifungal, and antioxidant properties. They were the first natural tropolones to be made synthetically.

Ticlatone (trade name Landromil) is an antifungal.

Chlorophetanol is an antifungal.

chemical compound

Sparassol is an antibiotic and antifungal isolated from Sparassis crispa.

Ethonam is an antifungal agent.

Cerulenin is an antifungal antibiotic that inhibits fatty acid and steroid biosynthesis. It was the first natural product antibiotic known to inhibit lipid synthesis. In fatty acid synthesis, it has been reported to bind in equimolar ratio to b-keto-acyl-ACP synthase, one of the seven moieties of fatty acid synthase, blocking the interaction of malonyl-CoA. It also has the related activity of stimulating fatty acid oxidation through the activation of CPT1, another enzyme normally inhibited by malonyl-CoA. Inhibition involves covalent thioacylation that permanently inactivates the enzymes. Thes

D75-4590 is an antifungal pyridobenzimidazole derivative that inhibits β-glucan synthesis. D11-2040 and D21-6076 are antifungal derivatives of D75-4590.

thumb|right Creolin (which is also called Creolina) is a generic name for disinfectants whose composition varies according to origin. It is extracted from the dry distillation of wood. The residue remaining in the autoclave vessel is a dark, syrupy mass called creosote, which is composed mainly of phenolic acid and cresylic acid. The original composition of creolin is a creosote tar oil, caustic soda, soaps, and very little water. It is of low technology and a very powerful disinfectant.

Fenticlor (also spelled fentichlor) is an antibacterial and antifungal agent for topical use. It is an antimicrobial agent. It is also used in veterinary medicine. __TOC__ ==Synthesis== It is prepared by the AlCl3-catalyzed reaction of 4-chlorophenol with sulfur dichloride. It can also be prepared by chlorination of bis[2-hydroxyphenyl]sulfide.