Aziridines

Aziridine is an organic compound consisting of the three-membered heterocycle . It is a colorless, toxic, volatile liquid that is of significant practical interest. Aziridine was discovered in 1888 by the chemist Siegmund Gabriel. Its derivatives, also referred to as aziridines, are of broader interest in medicinal chemistry.

chemical compound

thumb|right|Chemical structure of mitomycin C The mitomycins are a family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. They include mitomycin A, mitomycin B, and mitomycin C. When the name mitomycin occurs alone, it usually refers to mitomycin C, its international nonproprietary name. Mitomycin C is used as a medicine for treating various disorders associated with the growth and spread of cells.

name reaction

Propyleneimine (or propylene imine) is the organic compound with the formula CH3CH(NH)CH2. It is a secondary amine and the smallest chiral aziridine (ring containing C2N). It is a flammable colorless liquid. Its derivatives, copolymers and oligomers, are of commercial interest.

Metepa is a chemosterilant, with the capability to restrict ovarian development. Metepa can also result in carcinogenesis, in particular the formation of teratomas. It a minor ingredient in certain solid rocket propellants.