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Biological simulation video games

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Spore
2008 video game
Plague Inc.
2012 strategy video game
SimEarth
SimEarth: The Living Planet is a life simulation game, the second designed by Will Wright, published in 1990 by Maxis. In SimEarth, the player controls the development of a planet. English scientist James Lovelock served as an advisor and his Gaia hypothesis of planet evolution was incorporated into the game. Versions were made for the Macintosh, Atari ST, Amiga, IBM PC, Super Nintendo Entertainment System, Sega CD, and TurboGrafx-16. It was re-released for the Wii Virtual Console. In 1996, several of Maxis' simulation games were re-released under the Maxis Collector Series with greater compat
SimAnt
SimAnt: The Electronic Ant Colony is a 1991 life simulation video game by Maxis and the company's third product, focusing on the lifecycle of ants. It was designed by Will Wright. In 1992, it was named "Best Simulation Game" at the Software Publishers Association's Codie awards. SimAnt was re-released in 1993 as part of the SimClassics Volume 1 compilation alongside SimCity Classic and SimLife for MS-DOS, Mac and Amiga. In 1996, SimAnt, alongside several of Maxis' simulation games were re-released under the Maxis Collector Series with greater compatibility with Windows 95 and differing box art
Slime Rancher
2017 life simulation video game developed by Monomi Park
SimLife
SimLife: The Genetic Playground is a video game produced by Maxis in 1992. The concept of the game is to simulate an ecosystem; players may modify the genetics of the plants and animals that inhabit the virtual world. The point of this game is to experiment and create a self-sustaining ecosystem. SimLife was re-released in 1993 as part of the SimClassics Volume 1 compilation, alongside SimCity Classic and SimAnt for PC, Mac and Amiga.
SimAnimals
SimAnimals is a life simulation video game published by Electronic Arts for the Nintendo DS and Wii console systems. It was released on January 21, 2009, in North America. It was released on January 30, 2009, in Europe and on February 5, 2009, in Australia. A sequel, SimAnimals Africa, was released for Wii and Nintendo DS on October 27, 2009.
Slime Rancher 2
2025 video game
Shelter
2013 survival video game
E.V.O.: Search for Eden
1992 video game
Spore Galactic Adventures
video game
Mewgenics
Mewgenics is a 2026 tactical role-playing roguelike life simulation video game developed by Edmund McMillen and Tyler Glaiel. The gameplay revolves around the process of breeding cats that assume character classes and sending them out on adventures based on a series of tactical combats set up on procedurally-generated grids. Originally announced by Team Meat in 2012 as a follow-up to Super Meat Boy, the game experienced a protracted production cycle that led to a state of development hell, before being cancelled and subsequently reacquired by McMillen for development with Glaiel in 2018. Mewge
Seaman
1999 video game
WolfQuest
WolfQuest is a 3D wildlife simulation video game originally developed by the Minnesota Zoo and game developer company Eduweb, and developed solely by Eduweb since 2013. The game's main purpose is to help players understand wolves and the roles they play in nature by living the life of a gray wolf in Yellowstone National Park.
Osmos
Osmos is a 2009 puzzle video game developed by Canadian developer Hemisphere Games for various systems such as Microsoft Windows, Mac OS X, Linux, OnLive, iPad, iPhone, iPod Touch and Android. It was designed by Eddy Boxerman, founder of Hemisphere and a former developer at Ubisoft Montreal.
Spore Origins
2008 video game
Cell to Singularity
2018 video game
Spore Creatures
2008 video game
Spore Hero
2009 video game
Evolution: The Game of Intelligent Life
1997 video game
Creatures
1990s artificial life game series