Clinical trials

human subject research in medicine

1932—1972 human experiment in Alabama, USA

process by means of which a research participant agrees to be the subject of research

statistical measure of the magnitude of a phenomenon

Pharmacovigilance (PV, or PhV), also known as drug safety, is the discipline within pharmaceutical science that addresses the identification, evaluation, and mitigation of adverse effects and other drug-related problems associated with pharmaceutical products.

human experimentation conducted in Guatemala

international quality standard for conducting clinical trials involving human subjects

multinational Phase III-IV clinical trial organized by the World Health Organization (WHO) and partners to compare four untested treatments for hospitalized people with severe COVID-19 illness

vaccine against respiratory syncytial virus (RSV)

research study in which both the researcher and the participant know which treatment is being used

ClinicalTrials.gov is a registry of clinical trials. It is run by the United States National Library of Medicine (NLM) at the National Institutes of Health, and holds registrations from over 444,000 trials from 221 countries.

Form of study design and analysis for medical studies

occurrence or absence of disease, symptom, sign or laboratory abnormality constituting a target outcome in clinical research trials

procedure to independently assess the methodological quality of a clinical trial

untoward medical occurrence in human medical trials that is sufficiently serious and meeting criteria such as resulting in death, life-threatening situation, inpatient hospitalization, disability or incapacity, birth defect, or permanent impairment

method of assessing the certainty in evidence

type experimental design in a clinical trial

ChAdOx1 is an adenoviral vector for vaccines that was developed by the Jenner Institute, University of Oxford. The vector is a chimpanzee adenovirus modified to avoid its replication.

biomarker intended to substitute for a clinical endpoint

software system

long-term U.S. national health study that has focused on strategies for preventing the major causes of death, disability, and frailty in older women, specifically heart disease, cancer, and osteoporotic fractures

reporting standards for clinical trials

Cause and effect relationship in medicine

medicinal product not yet approved for routine use

Psychological experiment including prison inmates and the effects of psychedelics

practice of monitoring the safety of a pharmaceutical drug or medical device after it has been released on the market