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Design of experiments

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experiment
thumb|Apollo 15 astronaut [[David Scott performs a gravity test on the Moon with a hammer and feather (1971).]] thumb|right|160px|Even very young children perform rudimentary experiments to learn about the world and how things work.
confirmation bias
tendency of people to favor information that confirms their beliefs or hypotheses
analysis of variance
collection of statistical models used to analyze the differences between group means and their associated procedures
statistical test
method of statistical inference
clinical trial
human subject research in medicine
null hypothesis
statistical concept
randomized controlled trial
experimental method designed to reduce bias, typically accomplished by randomly allocating subjects to two or more groups, with one being a control group
blind experiment
experiment in which information about the test is masked to reduce bias
Latin square
square array with symbols that each occur once per row and column
dependent and independent variables
concept in mathematical modeling, statistical modeling and experimental sciences
design of experiments
scientific craft
Nuremberg Code
set of research ethics principles for human experimentation
longitudinal study
study with repeated observations over time
confounding
class=skin-invert-image|thumb|upright=1.3|Whereas a mediator is a factor in the causal chain (above), a confounder is a spurious factor incorrectly implying causation (bottom)
type I and type II errors
concepts from statistical hypothesis testing
data collection
process of gathering and measuring information
drug design
inventive process of finding new medications based on the knowledge of a biological target
case-control study
type of observational study comparing two existing groups differing in outcome
multicollinearity
In statistics, multicollinearity or collinearity is a situation where the predictors in a regression model are linearly dependent.
Fisher information
way of measuring the amount of information that an observable random variable carries about an unknown parameter of a distribution that models it
observational study
study that draws inferences from a sample to a population, in cases where the independent variable is not under the control of the researcher because of ethical concerns or logistical constraints
statistical variable
science and research term for a quality of a studied object
quasi-experiment
A quasi-experiment is a research design used to estimate the causal impact of an intervention. Quasi-experiments share similarities with experiments and randomized controlled trials, but specifically lack random assignment to treatment or control. Instead, quasi-experimental designs typically compare groups that are either preexisting (e.g., different dog breeds) or groups that were created without random assignment (e.g., students attending different universities).
randomization
Randomization is a statistical process in which a random mechanism is employed to select a sample from a population or assign subjects to different groups. The process is crucial in ensuring the random allocation of experimental units or treatment protocols, thereby minimizing selection bias and enhancing the statistical validity. It facilitates the objective comparison of treatment effects in experimental design, as it equates groups statistically by balancing both known and unknown factors at the outset of the study. In statistical terms, it underpins the principle of probabilistic equivalen
Bristol–Fisher–Roach randomised tasting trial
famous randomized experiment
factorial experiment
experiment whose design consists of two or more factors, each with discrete possible values, and whose experimental units take on all possible combinations of these levels across all such factors
observer-expectancy effect
form of reactivity in which a researcher's cognitive bias causes them to subconsciously influence the participants of an experiment
phase of clinical research
steps for human subject medical research
protocol
predefined written procedural method in the design and implementation of experiments in natural sciences
data dredging
use of data mining to uncover patterns in data that can be presented as statistically significant
difference in differences
social sciences statistical technique that mimics an experimental research design using observational study data by studying the differential effect of a treatment on a 'treatment group' versus a 'control group' in a natural experiment
Taguchi methods
statistical methods to improve the quality of manufactured goods
regression discontinuity design
statistical method
block design
set together with a family of subsets in math
open-label trial
research study in which both the researcher and the participant know which treatment is being used
Steiner system
A type of block design, specifically a t-design with λ = 1 and t ≥ 2.
interaction
in statistics, the situation in which the simultaneous influence of two variables on a third is not additive
multivariate analysis of variance
procedure for comparing multivariate sample means
design matrix
matrix of values of explanatory variables of a set of objects
ecological study
studies of risk-modifying factors on health or other outcomes based on populations defined either geographically or temporally
response surface methodology
sequential experimentation for improvement and for finding an optimal response
null result
in statistics, a non-significant result
combinatorial design
symmetric arrangement of finite sets
sequential analysis
statistical analysis where the sample size is not fixed in advance
self-selection bias
situation in which individuals select themselves into a group, causing a biased sample with nonprobability sampling
institutional review board
hospital or other institutional committees established to protect the welfare of research subjects
Jadad scale
procedure to independently assess the methodological quality of a clinical trial
random assignment
process involving chance used in research for allocating experimental subjects to groups
vaccine trial
clinical trial that aims at establishing the safety and efficacy of a vaccine prior to it being licensed
age adjustment
technique used to compare populations with different age profiles
field experiment
experiment conducted outside the laboratory
surrogate model
engineering method used when an outcome of interest cannot be easily directly measured, so a model of the outcome is used instead
randomized experiment
experiment using randomness in some aspect, usually to aid in removal of bias
crossover study
type experimental design in a clinical trial
group in an experiment
group of experimental subjects which the study's design treats in a distinct way
Wizard of Oz experiment
type of research experiment
Fisher's inequality
inequality encountered in block design
synthetic control method
causal inference method
Latin hypercube sampling
statistical method for generating a near-random sample of parameter values from a multidimensional distribution
group testing
A procedure that breaks up the task of identifying certain objects into tests on groups of items.