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Icadyptes salasi
Icadyptes is an extinct genus of giant penguins from the Late Eocene tropics of South America.

Perucetus
Perucetus is an extinct genus of an early whale from Peru that lived during the Bartonian age of the middle Eocene. Perucetus is the largest Eocene whale, with length estimates varying from to . It was initially claimed to have rivaled or exceeded the modern blue whale in weight, partly due to the incredibly thick and dense bones this animal possessed, coupled with its already great size, but subsequent studies argued that it was significantly lighter. The ecology of Perucetus also remains largely mysterious. Based on the fossils, it was likely a slow-moving inhabitant of shallow waters. Its d

Inkayacu
Inkayacu is a genus of extinct penguins. It lived in what is now Peru during the Late Eocene, around 36 million years ago. The only species, I. paracasensis, was named from a single nearly complete skeleton discovered in 2008. It includes fossilized feathers, the first known in penguins. A study of the melanosomes, pigment-containing organelles within the feathers, indicated that they were gray or reddish brown. This differs from modern penguins, which get their dark black-brown feathers from unique melanosomes that are large and ellipsoidal.

Niolamia
Niolamia is an extinct genus of South American meiolaniid turtle with a long and complex history. Like its relatives, Niolamia was a robust and heavily armored terrestrial turtle with large, horn like scales covering its head and a tail encased by rings of bone. This heavily armored build may have served the animal during intraspecific combat during courtship, though such encounters likely did not involve the horns and frill, which are thought to serve more of a display function. Scans of the skull reveal that Niolamia likely had a great sense of smell but only low frequency hearing, indicatin
Notostylops
Notostylops ("south pillar face") is a genus of extinct South American notoungulates from Eocene Argentina. Fossils of the genus have been found in the Sarmiento, Casamayor, Andesitas Huancache and Koluel Kaike Formations.
Image:Notostylopss.png|Size comparison of Notostylops murinus with a human.
Image:Notostylops murinus Wikipedia Juandertal.jpg|Life reconstruction.

Trigonostylops
Trigonostylops is an extinct genus of South American meridiungulatan ungulate, from the Late Paleocene to Late Eocene (Itaboraian to Tinguirirican in the SALMA classification) of South America (Argentina and Peru) and Antarctica (Seymour Island). It is the only member of the family Trigonostylopidae.

Barinasuchus
Barinasuchus (meaning "Barinas crocodile", in reference to where the type material was found) is an extinct genus of sebecid mesoeucrocodylian. It lived in Argentina, Peru, and Venezuela between the middle Eocene and the Late Miocene, ~42–11.6 Ma. Described in 2007, based on a severely damaged specimen from which only a snout tip was recovered, Barinasuchus is known from a single species, B. arveloi, named after Alberto Arvelo Torrealba, a local educator and poet.
Proborhyaenidae
Proborhyaenidae is an extinct family of metatherian mammals of the order Sparassodonta, which lived in South America from the Eocene (Mustersan) until the Oligocene (Deseadan). Sometimes it has been included as a subfamily of their relatives, the borhyaenids (as Proborhyaeninae). The largest species, Proborhyaena gigantea, is estimated to be about the size of a spectacled bear, with its skull reaching in length, and body mass estimates up to approximately , making the proborhyaenids some of the largest known metatherians. Proborhyaenid remains have been found in western Bolivia, Uruguay, south
Mystacodon
Mystacodon is a genus of toothed baleen whale from the Late Eocene Yumaque Member of Paracas Formation (previously called as Yumaque Formation) of the Pisco Basin in southwestern Peru. It is the oldest known baleen whale, and was probably a suction feeder of small prey on the seafloor.
Didolodus
Didolodus is an extinct genus of mammals from Middle Eocene Argentina. It is an ungulate mammal of uncertain affinities, possibly related to Litopterna, though this is uncertain due to the lack of reliable post-cranial remains, and for now remains Meridiungulata incertae sedis. Its remains were found in the Sarmiento Formation of Patagonia.
Madtsoia
Madtsoia is an extinct genus of madtsoiid snakes. It is known from the Eocene of Argentina (M. bai), the Paleocene of Brazil (M. camposi), the Late Cretaceous (Maastrichtian) of India (M. pisdurensis), and the Late Cretaceous (Maastrichtian) of Madagascar (M. madagascariensis). The type species (M. bai) was the largest with an estimated length of , and the other three species were smaller. A long M. madagascariensis would have weighed , but an isolated specimen suggests that this species reached in maximum length. Juvenile Madtsoia madagascariensis may have eaten a wide array of small vertebra
Supayacetus
Supayacetus is an extinct genus of basilosaurid cetacean from the Middle Eocene (Bartonian stage) Paracas Formation of Peru. It has been noted for its relatively small size and basal morphology, with the sternum bearing close resemblance to those of protocetids. Due to this, it has been traditionally placed as one of the basalmost basilosaurids, except for a 2023 study that places it within the family Pachycetinae close to Neoceti. Supayacetus is monotypic, meaning the genus includes only a single species: S. muizoni.
Campanorco inauguralis
Campanorco is an extinct genus of notoungulate mammal from the Middle Eocene Lumbrera Formation, Argentina, South America and the only member of the family Campanorcidae. It contains only a single species, Campanorco inauguralis.
Pseudoglyptodon chilensis
Pseudoglyptodon is a genus of extinct sloths from South America. The type species is Pseudoglyptodon sallaensis.
Ocucajea
Ocucajea is an extinct genus of basilosaurid cetacean from Middle Eocene (Bartonian stage) deposits of southern Peru. Ocucajea is known from the holotype MUSM 1442, a partial skeleton. It was collected in the Archaeocete Valley site, from the Paracas Formation of the Pisco Basin about .
Astraponotus
Astraponotus is an extinct genus of astrapotheriids. It lived during the Middle-Late Eocene (in the Mustersan and Tinguirirican of the South American land mammal ages (SALMA), 48-33.9 million years ago) and its fossil remains have been found in the Sarmiento Formation of Argentina, South America.
Allalmeia
Allalmeia was a small notoungulate mammal of around 3 kilograms. It lived in Mendoza Province, Argentina (Divisadero Largo Formation) during the Late Eocene. Allalmeia belonged to the Oldfieldthomasiidae family within the suborder Typotheria.