Email clients that use GTK

web browser with built-in email client

personal information manager software and workgroup information management tool for GNOME

GTK-based Email client

Sylpheed is an open-source e-mail client and news client licensed under GNU GPL-2.0-or-later with the library part LibSylph under GNU LGPL-2.1-or-later. It provides easy configuration and an abundance of features. It stores mail in the MH Message Handling System. Sylpheed runs on Unix-like systems such as Linux or BSD, and it is also usable on Windows. It uses GTK+.