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Fiction about orphans

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The Promised Neverland
Japanese manga series
Xenoblade Chronicles
2010 video game
Terror in Resonance
Japanese anime television series
Ori and the Blind Forest
2015 platform-adventure Metroidvania video game
Ori and the Will of the Wisps
2020 platform-adventure video game developed by Moon Studios
Bravely Default
2012 role-playing video game developed by Square Enix
Tegami Bachi
Japanese manga series
Blast of Tempest
Japanese manga series
Bloodstained: Ritual of the Night
2019 action-adventure video game
The Last Story
2011 video game
Drakengard
2003 video game
The Adventures of Rin Tin Tin
television program
+Anima
(stylized as +ANIMA) is a Japanese manga series written and illustrated by Natsumi Mukai. It was serialized in MediaWorks's manga magazine Dengeki Comic Gao! from December 1999 to January 2005, with its chapters collected in ten '''' volumes. The story focuses on four +Anima—humans who have metamorphic abilities, which has caused them to be shunned by society.
Dogs
Japanese manga series
Fragile Dreams: Farewell Ruins of the Moon
2009 video game
Honey Honey no Suteki na Bouken
Japanese manga series
Renegade Nell
British television series
Analogue: A Hate Story
2012 video game
The Two Orphans
French play of 1874 by Adolphe d'Ennery and Eugène Cormon
Borderliners
Borderliners is the English translation of De måske egnede, a novel written by Danish author Peter Høeg in 1993. It is about three children – Peter, Katarina, and August – who attend a private school in Copenhagen in the mid-1970s. It is not long before the children realise they are part of an experiment initiated by the school. The objective is to show how damaged children can be saved and made into citizens. The children choose to fight the experiment.