Historical polysubstance drinks

Cola is a carbonated soft drink flavored with vanilla, cinnamon, citrus oils, and other flavorings. The name, however, comes from the kola nut (Cola acuminata), which imbues the beverage with caffeine (though other sources of caffeine are generally used in modern formulations). A stimulating soda using kola appeared circa 1880.

sometimes called Brompton mixture, an elixir for pain prophylaxis