Isocyanides

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chemical compound

pharmaceutical drug

chemical compound

Trifluoromethylisocyanide is the chemical compound with the formula CF3NC. It is an isocyanide and a fluorocarbon. Polymerisation occurs even at temperatures below its boiling point of −80 °C. As a ligand in coordination chemistry, this species behaves similarly to carbon monoxide.

TosMIC (toluenesulfonylmethyl isocyanide) is an organic compound with the formula CH3C6H4SO2CH2NC. The molecule contains both sulfonyl and isocyanide groups. It is a colourless solid that, unlike many isocyanides, is odorless. It is prepared by dehydration of the related formamide derivative. It is used to convert ketones to nitriles (Van Leusen reaction) and in the preparation of oxazoles and imidazoles. The versatility of TosMIC in organic synthesis has been documented. It is a fairly strong carbon acid, with an estimated pKa of 14 (compared to 29 for methyl tolyl sulfone), the isocyano grou

Xantocillin (INN), also known as xanthocillin X or ophthocillin, was the first reported natural product found to contain the isocyanide functional group. It was first isolated from Penicillium notatum by Rothe in 1950 and subsequently from several other sources.

chemical compound