Monotypic Cucurbitaceae genera

Ecballium is a genus of flowering plants in the family Cucurbitaceae containing a single species, Ecballium elaterium, also called the squirting cucumber. Its unusual common name derives from the ripe fruit squirting a stream of mucilaginous liquid containing its seeds as a means of seed dispersal, an example of rapid plant movement.

Dendrosicyos is a monotypic genus in the plant family Cucurbitaceae. The only species is Dendrosicyos socotranus, the cucumber tree. The species is endemic to the island of Socotra in Yemen, and is the only species in the Cucurbitaceae to grow in a tree form. The species name was originally spelled D. socotrana, but this is corrected to masculine grammatical gender according to the International Code of Nomenclature for algae, fungi, and plants.

Echinocystis is a monotypic genus in the gourd family, Cucurbitaceae. The sole species is E. lobata, commonly called wild cucumber and prickly cucumber. It is an annual, sprawling plant that is native to North America. Sicyos angulatus, common name "bur cucumber", is an annual plant with a similar clinging vine growth but different-appearing flowers and seed pods.

Abobra is a monotypic genus of the gourd family containing the one species Abobra tenuifolia (syn. Abobra viridiflora Naudin, Bryonia tenuifolia Hook. & Arn.). It is a diecious, perennial climbing plant reaching up to the height of . It is native to South America (Argentina, Brazil, and Uruguay) and is sometimes cultivated as ornamental plants and also for its edible fruits. The flowers exude a strong fragrance and are of pale green color and blossom between July and August. The seeds ripen between September and October. The fruit is ovoid and has a diameter of 14 mm. Common names include cran

Zanonia is a monotypic genus in the flowering plant family Cucurbitaceae (the cucumber, squash, and pumpkin family). thumb|left|Botanical illustration of Zanonia indica. The only species is Zanonia indica, a medium-sized liana found in the Indian subcontinent and Southeast Asia east to New Guinea. It has a number of subspecies.

Peponopsis is a monotypic genus of flowering plants belonging to the family Cucurbitaceae. The only species is Peponopsis adhaerens.

Brandegea is a monotypic genus containing the single species Brandegea bigelovii, the desert starvine. This sprawling perennial vine in the squash family is native to the deserts of California, Arizona, and northern Mexico. The distinctive small, dark-green leaves are variable in shape but are usually a deeply lobed long-fingered palmate shape. They are heavily speckled with white oil glands. The vine bears tendrils, tiny five-pointed white flowers only 2 or 3 millimeters wide, and small, dry, prickly fruits 5 or 6 millimeters in length and holding a single seed. The plant grows from a deep ta

Oreosyce africana is a species of flowering plant in the cucumber family, Cucurbitaceae. It is the sole species in genus Oreosyce. It is a climber native to sub-Saharan Africa and Madagascar, ranging from Bioko and Cameroon to the west to Ethiopia to the northeast and Limpopo Province of South Africa to the south.

Nothoalsomitra suberosa is a species of subtropical vines in the family Cucurbitaceae, the only member of the monotypic genus Nothoalsomitra. Native to Queensland in Australia.

Doyerea is a monotypic genus of flowering plants belonging to the family Cucurbitaceae. The only species is D. emetocathartica.

Lemurosicyos is a monotypic genus of flowering plants belonging to the family Cucurbitaceae. The only species is Lemurosicyos variegatus.

Linnaeosicyos is a monotypic genus of flowering plants belonging to the family Cucurbitaceae. The only species is Linnaeosicyos amara ., which is endemic to the Dominican Republic.