Municipality seats in Tlaxcala

Huamantla () is a small city in the municipality of the same name in the eastern half of the Mexican state of Tlaxcala. The area has a long indigenous history, but the city itself was not founded until the early colonial period, in the 1530s. It is mostly agricultural but it is best known for its annual homage to an image of the Virgin Mary called Our Lady of Charity. This includes a month of festivities, the best known of which are the “night no one sleeps” when residents create six km of “carpets” on the streets made from colored sawdust, flowers and other materials. The other is the “Huaman

Apizaco is a city in Apizaco Municipality located near the geographic center of the Mexican state of Tlaxcala, approximately 25 minutes by car from the state's capital city of Tlaxcala. Those seeking to reach the port of Veracruz by railroad from Mexico City must travel through Apizaco. The city began because of its location on this railroad.

Calpulalpan, officially the Heroic City of Calpulalpan, is a Mexican city, head and main urban center of the homonymous municipality, located to the west of the state of Tlaxcala. With 33,263 inhabitants in 2010 according to the population and housing census conducted by the National Institute of Statistics and Geography (INEGI), it is the sixth most populous city in the state. It has an estimated population of 37,752 inhabitants for 2017, according to the National Population Council (CONAPO).