Ophiacodontidae

Archaeothyris is an extinct genus of ophiacodontid synapsid that lived during the Late Carboniferous and is known from Nova Scotia. Dated to 306 million years ago, Archaeothyris, along with a more poorly known synapsid called Echinerpeton, are the oldest undisputed synapsids known. The name means ancient window (Greek), and refers to the opening in the skull, the temporal fenestra, which indicates this is an early synapsid. Protoclepsydrops also from Nova Scotia is slightly older but is known by very fragmentary materials. thumb|Life restoration of Archaeothyris florensis

Ophiacodon (meaning "snake tooth") is an extinct genus of synapsid belonging to the family Ophiacodontidae that lived from the Late Carboniferous to the Early Permian in North America and Europe. The genus was named along with its type species O. mirus by paleontologist Othniel Charles Marsh in 1878 and currently includes five other species. As an ophiacodontid, Ophiacodon is one of the most basal synapsids and is close to the evolutionary line leading to mammals.

Ophiacodontidae is an extinct family of early eupelycosaurs from the Carboniferous and Permian. Archaeothyris, and Clepsydrops were among the earliest ophiacodontids, appearing in the Late Carboniferous. Ophiacodontids are among the most basal synapsids, an offshoot of the lineage which includes therapsids and their descendants, the mammals. The group became extinct by the Kungurian or the Roadian, replaced by anomodonts, theriodonts, and the diapsid reptiles.

Varanosaurus ('monitor lizard') is an extinct genus of early ophiacodontid synapsid that lived during the Artinskian and Kungurian ages of the Permian.

Clepsydrops is an extinct genus of primitive synapsids from the early Late Carboniferous that was related to Archaeothyris. The name means 'hour-glass appearance' (Greek klepsydra = "hourglass" + Greek ops = "eye, face, appearance").

Stereophallodon is an extinct genus of non-mammalian synapsids.

Baldwinonus is an extinct genus of basal synapsids from the Early Permian. The type species is Baldwinonus trux, named in 1940 from the Cutler Formation of New Mexico. A second species, Baldwinonus dunkardensis, was named in 1952 from Ohio. Baldwinonus was first classified in the family Eothyrididae, but the group has since been recognized as a wastebasket taxon for many early synapsids. More recently, Baldwinonus has been placed in the family Ophiacodontidae. Its phylogenetic relationship to other early synapsids remains poorly understood because it is only known from a few fragments of bone.

Stereorhachis is an extinct genus of non-mammalian synapsids from the Late Carboniferous of France. thumb|left|Restoration