Proteomics

thumb|A representation of the 3D structure of the protein myoglobin showing turquoise α-helices. This protein was the first to have its structure solved by [[X-ray crystallography. Toward the right-center among the coils, a prosthetic group called a heme group (shown in gray) with a bound oxygen molecule (red).]]

300px|thumb|right|Robotic preparation of MALDI [[mass spectrometry samples on a sample carrier]]

American chemist and AI expert

thumb|400px|General schema showing the relationships of the genome, [[transcriptome, proteome, and metabolome (lipidome).]]

constitutes one of the three main types of proteins (alongside globular and membrane proteins). There are many scleroprotein superfamilies including keratin, collagen, elastin, and fibroin

UniProt is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects. It contains a large amount of information about the biological function of proteins derived from the research literature. It is maintained by the UniProt consortium, which consists of several European bioinformatics organisations and a foundation from Washington, DC, US.

physical interactions and constructions between multiple proteins

degradation

thumb|Hundreds of gel drops are visible on the biochip.

DNA repair pathway

thumb|363x363px|Structure of human alpha-1-acid glycoprotein (AGP1) rendered in ChimeraX using PDB ID: 3KQ0 thumb|339x339px|Structure of human alpha-1-acid glycoprotein (AGP2) rendered in ChimeraX using PDB ID: 3APU Orosomucoid (ORM) or alpha-1-acid glycoprotein (α1AGp, AGP or AAG) is an acute phase protein found in plasma. Orosomucoid was discovered over 70 years ago and belongs to the lipocalin protein family. There are two isoforms of AGP, referred to as AGP1 and AGP2. It is an alpha-globulin glycoprotein and is modulated by two polymorphic genes. It is synthesized primarily in hepatocytes

PROSITE is a protein database. It consists of entries describing the protein families, domains and functional sites as well as amino acid patterns and profiles in them. These are manually curated by a team of the Swiss Institute of Bioinformatics and tightly integrated into Swiss-Prot protein annotation. PROSITE was created in 1988 by Amos Bairoch, who directed the group for more than 20 years. Since July 2018, the director of PROSITE and Swiss-Prot is Alan Bridge.

analytical method used to track the interactions and activities of proteins

molecular biology technique for determining protein-nucleic acid interactions in vitro

database of human proteins

scientific project coordinated by the Human Proteome Organization

various types of partially folded protein states found in mildly denaturing conditions (e.g. low pH, mild denaturant, or high temperature), collapsed with some native-like secondary structure and a dynamic tertiary structure

application of mass spectrometry

Proteostasis is the dynamic regulation of a balanced, functional proteome. The proteostasis network includes competing and integrated biological pathways within cells that control the biogenesis, folding, trafficking, and degradation of proteins present within and outside the cell. Loss of proteostasis is central to understanding the cause of diseases associated with excessive protein misfolding and degradation leading to loss-of-function phenotypes, as well as aggregation-associated degenerative disorders. Therapeutic restoration of proteostasis may treat or resolve these pathologies.

BOINC based World Community Grid volunteer computing subproject

Secretomics is a type of proteomics which involves the analysis of the secretome—all the secreted proteins of a cell, tissue or organism. Secreted proteins are involved in a variety of physiological processes, including cell signaling and matrix remodeling, but are also integral to invasion and metastasis of malignant cells. Secretomics has thus been especially important in the discovery of biomarkers for cancer and understanding molecular basis of pathogenesis. The analysis of the insoluble fraction of the secretome (the extracellular matrix) has been termed matrisomics.

project to map all cell types of humans

The secretome is the set of proteins expressed by an organism and secreted into the extracellular space. In humans, this subset of the proteome encompasses 13-20% of all proteins, including cytokines, growth factors, extracellular matrix proteins and regulators, and shed receptors. The secretome of a specific tissue can be measured by mass spectrometry and its analysis constitutes a type of proteomics known as secretomics.

Laboratory technique for quantitative proteomics