Thiophenes

3-Bromothiophene is an organosulfur compound with the formula C4H3BrS. It is a colorless liquid. It is a precursor to the antibiotic timentin and the vasodilator cetiedil.

Tenidap was a COX/5-LOX inhibitor and cytokine-modulating anti-inflammatory drug candidate that was under development by Pfizer as a promising potential treatment for rheumatoid arthritis, but Pfizer halted development after marketing approval was rejected by the FDA in 1996 due to liver and kidney toxicity, which was attributed to metabolites of the drug with a thiophene moiety that caused oxidative damage.

Penthienate is an anticholinergic and has actions similar to atropine. It reduces gastric motility and secretion and is used for the treatment of peptic ulcer and dyspepsia.

chemical compound

Tienoxolol is a beta adrenergic receptor antagonist.

3,4-Ethylenedioxythiophene (EDOT) is an organosulfur compound with the formula C2H4O2C4H2S. The molecule consists of thiophene, substituted at the 3 and 4 positions with an ethylene glycolyl unit. It is a colorless viscous liquid.

Thiophene-2-carboxaldehyde is an organosulfur compound with the formula C4H3SCHO. It is one of two isomeric thiophenecarboxaldehydes. It is a colorless liquid that often appears amber after storage. It is versatile precursor to many drugs including eprosartan, Azosemide, and Teniposide.

3-Methylthiophene is an organosulfur compound with the formula CH3C4H3S. It is a colorless, flammable liquid. It can be produced by sulfidation of 2-methylsuccinate. Like its isomer 2-methylthiophene, its commercial synthesis involvess vapor-phase dehydrogenation of suitable precursors. 3-Methylthiophene is a precursor to the drug thenyldiamine and the pesticide morantel.

Tiamenidine (BAN, USAN, INN, also known as thiamenidine, Hoe 440) is an imidazoline compound that shares many of the pharmacological properties of clonidine. It is a centrally-acting α2 adrenergic receptor agonist (IC50 = 9.1 nM). It also acts as an α1-adrenergic receptor agonist to a far lesser extent (IC50 = 4.85 μM). In hypertensive volunteers, like clonidine, it significantly increased sinus node recovery time and lowered cardiac output. It was marketed (as tiamenidine hydrochloride) by Sanofi-Aventis under the brand name Sundralen for the management of essential hypertension.

Chlorothen (trade name Thenclor) is an antihistamine and anticholinergic.

Gacyclidine (GK-11, OTO-313) is a psychoactive drug which acts as a dissociative via functioning as a non-competitive NMDA receptor antagonist. It is closely related to phencyclidine (PCP), and specifically, is a derivative of tenocyclidine (TCP). Gacyclidine exhibits neuroprotective effects similar to those of other NMDA receptor antagonists, with the advantage of being substantially less neurotoxic maybe due to its interaction with "non-NMDA" binding sites.

2-Bromothiophene is an organosulfur compound with the formula C4H3BrS. It is a colorless liquid. Unlike 3-bromothiophene, the 2-bromo isomer is prepared directly by partial bromination of thiophene. It is a precursor to several drugs, including tipepidine, ticlopidine, and clopidogrel.

Morantel is an anthelmintic drug used for the removal of parasitic worms in livestock. It affects the nervous system of worms given the drug is an inhibitor of acetylcholinesterase. It is derived in part from 3-methylthiophene. Morantel is closely related to pyrantel.

BW-723C86 is a tryptamine derivative drug which acts as a 5-HT2B receptor agonist. It has anxiolytic effects in animal studies, and is also used for investigating the function of the 5-HT2B receptor in a range of other tissues.

chemical compound

Sitaxentan sodium (TBC-11251) is a medication for the treatment of pulmonary arterial hypertension (PAH). It was marketed as Thelin by Encysive Pharmaceuticals until Pfizer purchased Encysive in February 2008. In 2010, Pfizer voluntarily removed sitaxentan from the market due to concerns about liver toxicity.

Protiofate is a drug that has antimycotic activity and used in gynecology to treat yeast infections.

chemical compound