Tunica-Biloxi

parish in Louisiana, United States

city in and parish seat of Avoyelles Parish, Louisiana, United States

The Mosopelea or Ofo (also Ofogoula) were a Native American people who historically lived near the upper Ohio River. In reaction to Iroquois Confederacy invasions to take control of hunting grounds in the late 17th century, they moved south to the lower Mississippi River. They finally settled in central Louisiana, where they assimilated with the Tunica and the Biloxi. They spoke the Ofo language, generally classified as a Siouan language.

The Tunica-Biloxi Indian Tribe (), formerly known as the Tunica-Biloxi Indian Tribe of Louisiana, is a federally recognized tribe of primarily Tunica and Biloxi people, located in east central Louisiana. Descendants of Ofo (Siouan-speakers), Avoyel, and Choctaw are also enrolled in the tribe.

The Avoyel or Avoyelles were a small Native American tribe who at the time of European contact inhabited land near the mouth of the Red River at its confluence with the Atchafalaya River near present-day Marksville, Louisiana. Today, the Avoyel are a member of the federally recognized Native American tribe and sovereign nation of the Tunica Biloxi Tribe of Louisiana.