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Video games about viral outbreaks

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The Last of Us
2013 action-adventure video game developed by Naughty Dog
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2008 cooperative first-person shooter arcade-style video game by Valve Corporation
The Last of Us Part II
2020 action-adventure video game developed by Naughty Dog
Left 4 Dead 2
2009 cooperative first-person shooter video game by Valve Corporation
Deus Ex
2000 video game
Bloodborne
is a 2015 action role-playing game developed by FromSoftware and published by Sony Computer Entertainment for the PlayStation 4. The game follows a Hunter through the decrepit Gothic, Victorian-era inspired city of Yharnam, whose inhabitants are afflicted with a blood-borne disease which transforms the residents into horrific beasts. Attempting to find the source of the plague, the player's character unravels the city's mysteries while fighting beasts and cosmic beings.
Prototype
2009 action-adventure open world video game
Metal Gear Solid V: The Phantom Pain
2015 open world action-adventure stealth video game
Tom Clancy's The Division
2016 multi-genre video game developed by Ubisoft
Resident Evil 2
2019 survival horror video game remake developed by Capcom
Call of Duty: Black Ops III
2015 first-person shooter video game
Plague Inc.
2012 strategy video game
Resident Evil 3
2020 survival horror video game remake developed by Capcom
Warframe
Warframe is a free-to-play action role-playing third-person shooter multiplayer online game developed and published by Digital Extremes. First released for Windows in March 2013, it was later ported to PlayStation 4 in November 2013, Xbox One in September 2014, Nintendo Switch in November 2018, PlayStation 5 in November 2020, Xbox Series X/S in April 2021, iOS in February 2024, Android in Canada on February 11, 2026 followed by a global release on February 18, 2026, and was released on Nintendo Switch 2 on March 25, 2026. Support for cross-platform play was released in 2022. Cross-platform sav
Resident Evil 4
2023 video game developed by Capcom
Resident Evil
2002 survival horror video game remake
Prototype 2
2012 video game
Dying Light 2 Stay Human
2022 survival role-playing video game by Techland
A Plague Tale: Innocence
2019 action-adventure stealth video game developed by Asobo Studio
Days Gone
2019 action-adventure survival horror video game developed by SIE Bend Studio
DayZ
2018 survival video game
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2013 open world survival horror video game
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2014 action-adventure game developed by Naughty Dog, DLC for the video game The Last of Us
The Callisto Protocol
2022 third-person survival horror video game developed by Striking Distance Studios
Back 4 Blood
2021 cooperative first-person shooter video game developed by Turtle Rock Studios
Tom Clancy's The Division 2
2019 online action role-playing video game
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2019 cooperative third-person shooter video game developed by Saber Interactive
Mega Man 10
2010 video game
Dark Sector
2008 video game
The Last of Us Part I
2022 action-adventure video game developed by Naughty Dog; remake version of 2013 video game The Last of Us
A Plague Tale: Requiem
2022 video game developed by Asobo Studio
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video game series
Mega Man X3
1995 video game developed by Capcom
Dead Cells
2018 roguelike action platformer video game
Mega Man X5
2000 video game developed by Capcom Production Studio 3
Syphon Filter
1999 third-person shooter stealth video game developed by Eidetic
Pathologic
Pathologic ( – a pun on Thomas More's Utopia and the Russian word for "plague, pestilence" (мор)) is a 2005 survival game developed by Russian studio Ice-Pick Lodge. The game was released in Russia by Buka Entertainment in June 2005, followed by a localised English release from G2 Games and GMX Games in 2006. An updated version, Pathologic Classic HD, was developed by General Arcade, published by Good Shepard Entertainment, and released in October 2015. A remake of the Haruspex route was developed by Ice-Pick Lodge in the Unity game engine and released as Pathologic 2 in May 2019 by tinyBuild.
Zero Time Dilemma
2016 video game
Mega Man X6
2001 video game developed by Capcom
TimeSplitters 2
2002 video game
Zero Escape: Virtue's Last Reward
2012 Japanese visual novel
Dying Light: The Beast
2025 video game developed by Techland
Plague Inc: Evolved
2015 strategy and simulation game by Ndemic Creations
The Amazing Spider-Man
2012 video game
Shellshock 2: Blood Trails
2009 video game
Resident Evil: Resistance
2020 survival horror multiplayer video game, part of the Resident Evil 3 package
Nightmare Creatures
1997 video game
Ninja Blade
2009 video game
POD
1997 video game
Daymare: 1998
2019 survival horror action adventure video game developed by Invader Studios
Bio-Hazard Battle
1992 video game
Dying Light: The Following
2016 video game
Zarch
Zarch (also released as Virus) is a 3D video game developed by David Braben in 1987 for the launch of the Acorn Archimedes computer. Zarch started off as a demo called Lander which was bundled with almost all release of the Acorn Archimedes.
The Last Hope: Dead Zone Survival
2023 video game developed by VG Games
Outpost 2
1997 video game
Kabuki Quantum Fighter
1991 video game
Quarantine
1994 video game
Pathologic 2
2019 video game