'''trans-2-Phenyl-1-cyclohexanol''' is an organic compound. The two enantiomers of this compound are used in organic chemistry as chiral auxiliaries.
'''trans-2-Phenyl-1-cyclohexanol' is an organic compound. The two enantiomers of this compound are used in organic chemistry as chiral auxiliaries.
==Preparation== The enantioselective synthesis was accomplished by J. K. Whitesell by adding Pseudomonas fluorescens lipase to racemic trans-2-phenylcyclohexyl chloroacetate. This enzyme is able to hydrolyze the ester bond of the (−)-enantiomer but not the (+)-enantiomer. The (−)-cyclohexanol and the (+)-ester are separated by fractional crystallization and the isolated (+)-ester hydrolyzed to the (+)-cyclohexanol in a separate step.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).