azaprocin
Sign in to saveAzaprocin is a drug which is an opioid analgesic with approximately ten times the potency of morphine, and a fast onset and short duration of action. It was discovered in 1963, but has never been marketed.
Wikidata facts
- Mass
- 284.18886338799996
Show 4 more facts
- isomeric SMILES
- CCC(=O)N1[C@@H]2CC[C@@H]1CN(C2)C/C=C/C3=CC=CC=C3
- chemical formula
- C₁₈H₂₄N₂O
- canonical SMILES
- CCC(=O)N1C2CCC1CN(CC=Cc1ccccc1)C2
- Commons category
- Azaprocin
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Azaprocin is a drug which is an opioid analgesic with approximately ten times the potency of morphine, and a fast onset and short duration of action. It was discovered in 1963, but has never been marketed.
Para-nitroazaprocin, the derivative substituted on the phenyl ring with a p-nitro group, is more potent than the parent compound, around 25× the potency of morphine. The ring-opened 2,6-dimethylpiperazine analogues are also active, and a large family of opioid analgesic compounds derived from this parent structure have been developed over the last 40 years. One analogue, AP-237, has been used in China to treat the pain caused by cancer.