selective serotonin reuptake inhibitor
Also known as SSRI, serotonergic antidepressants, Inhibitors, 5-HT Uptake, Serotonin Reuptake Inhibitors, Inhibitors, Serotonin Reuptake, Uptake Inhibitors, Serotonin, Uptake Inhibitors, 5-Hydroxytryptamine, Reuptake Inhibitors, Serotonin
class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders
Key facts
- Synonyms
- Serotonin-specific reuptake inhibitors, serotonergic antidepressants
- Use
- Major depressive disorder , anxiety disorder , post-traumatic stress disorder , eating disorder
- Atc code
- N06AB
- Biological target
- Serotonin transporter
- Drugs com
- Drug Classes
- Consumer reports
- Best Buy Drugs
- Mesh
- D017367
via Wikipedia infobox
Article
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions.
SSRIs primarily work by blocking serotonin reabsorption (reuptake) via the serotonin transporter, leading to gradual changes in brain signaling and receptor regulation, with some also interacting with sigma-1 receptors, particularly fluvoxamine, which may contribute to cognitive effects. Marketed SSRIs include six main antidepressants—citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline—and dapoxetine, which is indicated for premature ejaculation. Fluoxetine has been approved for veterinary use in the treatment of canine separation anxiety.