Tasuku Honjo
Japanese professor of immunology and genomic medicine (1942–)
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Tasuku Honjo is a Japanese immunology researcher who discovered a key mechanism that helps the immune system recognize and attack cancer cells, work that earned him the Nobel Prize in Physiology or Medicine in 2018. His discovery has led to new cancer treatments that have helped improve outcomes for patients with various types of cancer worldwide.
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Recent publications · Crossref
5 total works indexed
- Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation
· 2000 · cited 4,386x
- Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
· 2000 · cited 2,878x
- Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
· 2002 · cited 2,701x
- Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.
· 1992 · cited 2,635x
- PD-L2 is a second ligand for PD-1 and inhibits T cell activation
· 2001 · cited 2,402x
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Tasuku Honjo (本庶 佑, Honjo Tasuku; born January 27, 1942) is a Japanese physician-scientist and immunologist. He won the 2018 Nobel Prize in Physiology or Medicine and is best known for his identification of programmed cell death protein 1 (PD-1). He is also known for his molecular identification of cytokines IL-4 and IL-5, as well as the discovery of activation-induced cytidine deaminase (AID) that is essential for class switch recombination and somatic hypermutation.
He was elected as a foreign associate of the National Academy of Sciences of the United States (2001), as a member of German Academy of Natural Scientists Leopoldina (2003), and also as a member of the Japan Academy (2005).
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1942 births20th-century Japanese biochemists21st-century Japanese biochemistsAcademic staff of Kyoto UniversityAcademic staff of Osaka UniversityAcademic staff of the University of TokyoForeign associates of the National Academy of SciencesImmunotherapyJapanese immunologistsJapanese Nobel laureatesKyoto laureates in Basic SciencesKyoto University alumni