Also known as Ruppert-Prakash reagent
Trifluoromethyltrimethylsilane (known as Ruppert-Prakash reagent, TMSCF3) is an organosilicon compound with the formula CF3Si(CH3)3. It is a colorless liquid. The compound is a reagent used in organic chemistry for the introduction of the trifluoromethyl group.
Trifluoromethyltrimethylsilane (known as Ruppert-Prakash reagent, TMSCF3) is an organosilicon compound with the formula CF3Si(CH3)3. It is a colorless liquid. The compound is a reagent used in organic chemistry for the introduction of the trifluoromethyl group.
==History== The compound was first prepared in 1984 by Ingo Ruppert It was further developed as a reagent by G. K. Surya Prakash, who reported activation of TMSCF3 by fluoride to perform nucleophilic trifluoromethylation of carbonyl compounds. In the same year, Stahly described similar reactions for the synthesis of trifluoromethylated phenols and anilines. Since then TMSCF3 has been widely used as a nucleophilic trifluoromethylating agent. Potassium (trifluoromethyl)trimethoxyborate for this purpose has been synthesised from B(OMe)3, CF3SiMe3 and KF. Aryl functionalization by C-H activation has also been reported.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).