debilitating

“Akeley, Noyes hastened to inform me, was glad and ready to see me; although his sudden attack of asthma would prevent him from being a very competent host for a day or two. These spells hit him hard when they came, and were always accompanied by a debilitating fever and general weakness.”

“All of which is to say – my OCD is back. For those of you who have not had the displeasure, OCD stands for Obsessive Compulsive Disorder and it is an absolute arseache. Again, at best. Utterly debilitating and life-ruining at worst.”