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psychosis

noun

  1. abnormal condition of the mind that involves a loss of contact with reality
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Wiktionary

Pronunciation: /saɪˈkəʊsɪs/ / /saɪˈkoʊsɪs/

noun

Etymology: From psych- + -osis or from Ancient Greek ψύχωσις (psúkhōsis, “animation, principle of life”).

  1. A severe mental disorder, sometimes with physical damage to the brain, marked by a deranged personality and a distorted view of reality.

    Manganism has been known about since the 19th century, when miners exposed to ores containing manganese[…]began to totter, slur their speech and behave like someone inebriated. The poisoning was irreversible, and soon ended in psychosis and death.