1521 deaths

Portuguese explorer in the service of Spain

pope from 1513 to 1521 (1475-1521)

Spanish explorer and conquistador

King of Portugal from 1495 to 1521

composer of the Renaissance (c. 1450–1521)

German humanist and satirist

emperor of the Ming Dynasty

Saxon princess who became Queen consort of Denmark, Norway, and Sweden

75th Doge of Venice (1436-1521), 1501-1521

Italian Catholic cardinal (1461-1521)

Portuguese explorer and writer (1480–1521)

Portuguese explorer

Catholic cardinal (1442-1521)

Portuguese explorer

French noble (1491-1521)

Duke of Cleves

Al-Mustamsik (, Abū ṣ-Ṣabr Yaʿqūb al-Mustamsik bi-Llāh; died 1521) was the sixteenth and penultimate Abbasid caliph of Cairo under the tutelage of the Mamluk Sultanate. He served as caliph twice, his first term from 1497 to 1508 and his second term from 1516 to 1517, when he abdicated the position to his son, al-Mutawakkil III. {| class="wikitable collapsible collapsed" border="1" style="width:100%; text-align:center;" !The genealogy of the Abbasids including their rival Zaydi imams |- |

English noble (1478-1521)

Prince of Wallachia and Romanian Saint

French miniature painter and manuscript illuminator (1457-1521)

Italian physician and writer

politician (1458-1521)

Spanish rebel

French duchess

Concubine of Bayezid II

Abd-Allah Hatefi, commonly known as Hatefi (also spelled Hatifi; ; 1454 – 1521) was a Persian poet and nephew of the distinguished poet Jami (died 1492).

Flemish painter and draftsman of the Northern Renaissance

French priest

English Renaissance composer

Grand Master of the Knights Hospitaller

Swedish archbishop of Uppsala (1430–1521)

Tlaxcaltec prince

Saint and siddha of the Nyingma school of Tibetan Buddhism

1521

Lithuanian noble

Duchess of Braganza

scientist

mistress of Christopher Columbus

Italian cardinal

Portuguese pilot and captain and Spanish explorer

Ming dynasty prince

Ottoman statesperson of Slovene origin (14..–1521)

Castilian rebel

Princess of Anhalt by birth, by marriage Duchess of Saxony

English noble

Spanish Dominican missionary

duke

Polish princess, mother of King John I of Hungary

Queen Dowager of Joseon

sculptor, carver (1480-1540)

Italian Roman Catholic priest

Italian sculptor (1460-1521)

English soldier, administrator and diplomat (1459-1521)

Austrian noble, manager and military person, ancestor of the Dutch (De) Graeff family line

German sculptor (ca. 1460–1521)

Spanish rebel

the second wife of Henry III of Nassau-Breda, whom she had married in 1515

Florentine aristocrat

general the of Samma Dynasty of Sindh

Czech hofmeister, marshal, fish farmer and nobleman