Alkylating agents

chemical compound

1-Bromobutane is the organobromine compound with the formula CH3(CH2)3Br. It is a colorless liquid, although impure samples appear yellowish. It is insoluble in water, but soluble in organic solvents. It is primarily used as a source of the butyl group in organic synthesis. It is one of several isomers of butyl bromide.

chemical compound

chemical compound

1-Bromopropane (also known as '''n-propyl bromide or nPB''') is a bromoalkane with the chemical formula CH3CH2CH2Br. It is a colorless, flammable liquid that is used as a solvent. It has a characteristic hydrocarbon odor. Its industrial applications increased dramatically in the 21st century due to the phasing out of chlorofluorocarbons and chloroalkanes such as 1,1,1-trichloroethane under the Montreal Protocol. It was also used as a dry cleaning solvent as a substitute for perchloroethylene for a short time in the United States. 1-Bromopropane is highly neurotoxic to humans.

forbidden potent and persisting lachrymatory agent

Phenoxybenzamine (PBZ), sold under the brand names Dibenzyline and Dibenyline, is a non-selective, irreversible alpha blocker.

2-Bromopropane, also known as isopropyl bromide and 2-propyl bromide, is the halogenated hydrocarbon with the formula CH3CHBrCH3. It is a colorless liquid. It is used for introducing the isopropyl functional group in organic synthesis. 2-Bromopropane is prepared by heating isopropanol with hydrobromic acid.

chemical compound

pharmaceutical drugs

chemical compound

Iodoacetamide (IAA) is an organic compound with the chemical formula . It is an alkylating agent used for peptide mapping purposes. Its actions are similar to those of iodoacetate. It is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds. It is also used in ubiquitin studies as an inhibitor of deubiquitinase enzymes (DUBs) because it alkylates the cysteine residues at the DUB active site.

chemical compound

chemical compound

chemical compound

chemical compound

chemical compound

chemical compound

chemical compound

1-Chlorohexane is a chemical compound from the group of aliphatic saturated halogenated hydrocarbons. The chemical formula is .

Naloxazone is an irreversible μ-opioid receptor antagonist which is selective for the μ1 receptor subtype. Naloxazone produces very long lasting antagonist effects as it forms a covalent bond to the active site of the μ-opioid receptor, thus making it impossible for the molecule to unbind and blocking the receptor permanently until the receptor is recycled by endocytosis.

Oxymorphazone is an opioid analgesic drug related to oxymorphone. Oxymorphazone is a potent and long acting μ-opioid agonist which binds irreversibly to the receptor, forming a covalent bond which prevents it from detaching once bound. This gives it an unusual pharmacological profile, and while oxymorphazone is only around half the potency of oxymorphone, with higher doses the analgesic effect becomes extremely long lasting, with a duration of up to 48 hours when administered intraventricularly. However, tolerance to analgesia develops rapidly with repeated doses, as chronically activated opio

β-Chlornaltrexamine (β-CNA) is a non-selective irreversible antagonist of the μ-opioid receptor (MOR), the δ-opioid receptor (DOR), and the κ-opioid receptor (KOR), which forms a covalent bond to the binding sites of these receptors and has ultra-long-lasting opioid antagonist effects. Although it is predominantly antagonistic, β-CNA also shows some irreversible mixed agonist–antagonist activity at the MOR and KOR and some associated analgesic effects. Its alkylating group is a bis(chloroalkyl)amino-residue similar to that of the nitrogen mustards.

chemical compound

1-Fluorohexane is a chemical compound from the group of aliphatic saturated halogenated hydrocarbons. The chemical formula is .

1-Iodohexane is a chemical compound from the group of aliphatic saturated halogenated hydrocarbons. The chemical formula is . It is a colorless liquid.

chemical compound

chemical compound

Pindobind is a compound developed by researchers associated with Stanford University, identified as a central nervous system depressant, which generated a response in animals reducing offensive actions such as chasing, while also notably reducing tendencies of the test animal to evade when stimulated to do so. It acts as an irreversible beta blocker and irreversible 5-HT1A receptor antagonist.

chemical compound