Aromatic ketones

Tenidap was a COX/5-LOX inhibitor and cytokine-modulating anti-inflammatory drug candidate that was under development by Pfizer as a promising potential treatment for rheumatoid arthritis, but Pfizer halted development after marketing approval was rejected by the FDA in 1996 due to liver and kidney toxicity, which was attributed to metabolites of the drug with a thiophene moiety that caused oxidative damage.

Danielone is a phytoalexin found in the papaya fruit. This compound showed high antifungal activity against Colletotrichum gloesporioides, a pathogenic fungus of papaya. A laboratory synthesis of danielone has been reported.

2,4-Diacetylphloroglucinol or Phl is a natural phenol found in several bacteria:

2,4,6-Trihydroxyacetophenone (THAP) is a chemical compound that is a derivative of phloroglucinol.

chemical compound

1,9-Pyrazoloanthrone is a chemical compound that is a derivative of anthrone. It is used in biochemical studies as an inhibitor of c-Jun N-terminal kinases (JNKs).

3,4-Methylenedioxypropiophenone, also known as 3,4-(methylenedioxy)phenyl-1-propanone (MDP1P), is a phenylpropanoid found in some plants of the genus Piper and is an isomer of 3,4-methylenedioxyphenyl-2-propanone (MDP2P).

Benzoylacetone is the organic compound with the nominal formula C6H5C(O)CH2C(O)CH3. As a 1,3-dicarbonyl, it is a precursor to many heterocycles, such as pyrazoles. It exists predominantly as the enol tautomer C6H5C(OH)=CHC(O)CH3. Its conjugate base (pKa=8.7) forms stable complexes with transition metals and lanthanides.

Acrylophenone is an organic compound with the formula C9H8O. It is prepared using acetophenone, formaldehyde, and an amine hydrochloride in a Mannich reaction. It can be polymerized to poly(phenylvinyl ketone) via radical or anionic mechanisms. It is sometimes used as a comonomer in the manufacturing of certain resins.

Picein is a phenolic compound found in mycorrhizal roots of Norway spruces (Picea abies). It is the glucoside of piceol.

'''N-Methylspiperone (NMSP''') is a derivate of spiperone that is used to study the dopamine and serotonin neurotransmitter systems. Labeled with the radioisotope carbon-11, it can be used for positron emission tomography.

Carboxyamidotriazole is a calcium channel blocker that blocks voltage-gated and ligand-gated calcium channels and has been investigated as an anti-cancer drug in vitro.

1,1-Diphenylacetone is an organic compound composed of a benzhydryl group and a methyl group attached to a central carbonyl group.

pharmaceutical drug

Pterulone is a fungal metabolite. It was initially isolated from the mycelium and liquid cultures of wood-decay fungus in the genus Pterula. The compound inhibits eukaryotic respiration by targeting the mitochondrial NADH:ubiquinone oxidoreductase.

'''4'-Aminopropiophenone (para-aminopropiophenone or PAPP''') is a chemical compound. It is highly toxic, and can cause injury or death upon physical contact or inhalation of fumes.

Indigoidine is an organic compound of the azaquinone group. It is a blue pigment produced by some bacterial species that excrete it into the surrounding medium.

MRS-1706 is a selective inverse agonist for the adenosine A2B receptor. It inhibits release of interleukins and has an antiinflammatory effect.

Capillin is a toxic naturally occurring organic compound with the chemical formula . The structure contains acetophenone and a polyyne (pentadiynyl) portion, conjugated together as an ynone.

Divaplon (RU-32698) is a nonbenzodiazepine, anxiolytic and anticonvulsant drug from the imidazopyrimidine family of drugs. It acts as a partial agonist at the "benzodiazepine site" of the GABAA receptor in the brain.

Etafenone is a vasodilator which has been used as an antianginal agent.

Acetylpyrazine is an organic compound with the chemical formula . It is a yellow-brown powder at room temperature. Chemically, acetylpyrazine is a pyrazine and a ketone. ==Natural occurrence== Acetylpyrazine is found in foods such as seeds, nuts and meats. ==Uses== It is used in frozen dairy products such as ice cream.

Aceprometazine (INN) is a phenothiazine derivative prescription drug with neuroleptic and anti-histamine properties It is not widely prescribed, and may be associated with drug-induced Parkinsonism. It may be used in combination with meprobamate for the treatment of sleep disorders. This combination is available in France under the trade name Mepronizine.

Nafimidone is an anticonvulsant drug of the imidazole class. It contains a naphthyl group. It seems to have been discovered by accident during a search for antifungal agents.