Benzodiazepine prodrugs

Rilmazafone (リスミー, Rhythmy, previously known as 450191-S) is a water-soluble prodrug developed by Shionogi. Inside the human body, rilmazafone is converted into several benzodiazepine metabolites that have sedative and hypnotic effects.

Avizafone (Pro-Diazepam) is a water-soluble prodrug of the benzodiazepine derivative diazepam. It can be administered intramuscularly.