Causes of amputation

Cancer is a group of diseases involving uncontrolled cell growth typically resulting in tumors with the potential to invade or spread to other parts of the body. These malignant tumors contrast with benign tumors, which do not spread. Over 100 types of cancers affect humans.

Diabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. Diabetes tends to progress in severity, and is due to either a reduced production of the hormone insulin by the pancreas or unresponsiveness of bodily cells to insulin's effects. Classic symptoms include the three Ps: polydipsia (excessive thirst), polyuria (excessive urination), and polyphagia (excessive hunger), together with weight loss and blurred vision. If left untreated, the disease can lead to many health complications, including disorders of the ca

thumb|Gangrenous toes in a diabetic

Sepsis is a potentially life-threatening condition that arises when the body's dysregulated response to infection causes injury to its own tissues and organs.

Frostbite is an injury to skin or other living tissue that is allowed to freeze, especially affecting the fingers, toes, nose, ears, cheeks and chin. Most often, frostbite occurs in the hands and feet, often preceded by frostnip, a paling or reddening of a body part as its blood vessels constrict that tingles, feels very cold, or simply feels numb. This may be followed by the clumsiness and white or bluish, waxy-looking skin that evidence full-blown frostbite. Swelling or blistering may occur following treatment. Complications may include hypothermia or compartment syndrome.

thumb|upright=1.6|Structural changes of cells undergoing necrosis and apoptosis

Thalidomide, sold under the brand names Contergan, Distaval and Thalomid among others, is an oral administered medication used to treat a number of cancers (e.g., multiple myeloma), graft-versus-host disease, and many skin disorders (e.g., complications of leprosy such as skin lesions). Thalidomide has been used to treat conditions associated with HIV: aphthous ulcers, HIV-associated wasting syndrome, diarrhea, and Kaposi's sarcoma, but increases in HIV viral load have been reported.

infection that results in the death of the body's soft tissue

An osteosarcoma (OS) or osteogenic sarcoma (OGS) is a cancerous tumor in a bone. Specifically, it is an aggressive malignant neoplasm that arises from primitive transformed cells of mesenchymal origin (and thus a sarcoma) and that exhibits osteoblastic differentiation and produces malignant osteoid.

tumor or cancer located in bone tissue or specific bones

non-freezing cold injury to the foot

human disease

type of conical projectile for mid 19th century rifles

medical condition

attack on a human by a shark

condition in which increased pressure within one of the body's compartments results in insufficient blood supply to tissue within that space

human disease

condition in which a person experiences a permanent intention to have a physical disability

human disease

Ainhum (from Portuguese, ), also known as dactylolysis spontanea, is a painful constriction of the base of the fifth toe frequently followed by bilateral spontaneous autoamputation a few years later.

injury by an object that causes compression of part or all of the body

congenital absence of the fibula

Human disease

human disease

Hemimelia is a birth defect consisting in unilateral or bilateral underdevelopment of the distal part of the lower or upper limb. The affected bone may be shortened or not develop at all.