Idiopathic diseases

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) or '''Lou Gehrig's disease''', is a rare terminal neurodegenerative disease defined by the progressive loss of both upper and lower motor neurons that normally control voluntary muscle contraction. ALS is the most common of the motor neuron diseases. ALS often presents in its early stages with gradual muscle stiffness, twitches, weakness, and wasting. Motor neuron loss typically continues until the ability to eat, speak, move, and breathe without mechanical support is lost. It is estimated that at least 50% of people

primary thrombocytopenia that involves relatively few platelets in blood as a result of autoantibodies

rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located in joint

disease with unknown pathogenesis or apparently spontaneous origin

Dermatomyositis (DM) is a long-term inflammatory autoimmune disorder which affects the skin and the muscles. Its symptoms are generally a skin rash and worsening muscle weakness over time. These may occur suddenly or develop over months. Other symptoms may include weight loss, fever, lung inflammation, or light sensitivity. Complications may include calcium deposits in muscles or skin.

chronic, irreversible and ultimately fatal disease characterized by a progressive decline in lung function

myeloid neoplasm that is located in the bone marrow which results in bone marrow being replaced by fibrous (scar) tissue

calcinosis that is the calcification or a bony hardening of ligaments in areas where they attach to the spine

pneumonia located in the lung parenchyma of unknown cause

degenerative corneal condition

Unknown disease outbreak in India, 2020

Systemic inflammatory disorder, and a subtype of juvenile idiopathic arthritis, associated with fever, rash, and arthritis.

Rapid-onset obesity with hypothalamic dysregulation, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare condition whose etiology is currently unknown. ROHHAD mainly affects the endocrine system and autonomic nervous system, but patients can exhibit a variety of signs. Patients present with both alveolar hypoventilation along with hypothalamic dysfunction, which distinguishes ROHHAD from congenital central hypoventilation syndrome (CCHS). ROHHAD is a rare disease, with only 100 reported cases worldwide thus far.

connective tissue disease characterized by ectopic ossification of the posterior longitudinal spinal ligament resulting in spinal cord compression, myelopathy and hyperreflexia