Isoquinoline alkaloids

Reserpine is a drug that is used for the treatment of high blood pressure, usually in combination with a thiazide diuretic or vasodilator. Large clinical trials have shown that combined treatment with reserpine plus a thiazide diuretic reduces mortality of people with hypertension. Although the use of reserpine as a solo drug has declined since it was first approved by the FDA in 1955, the combined use of reserpine and a thiazide diuretic or vasodilator is still recommended in patients who do not achieve adequate lowering of blood pressure with first-line drug treatment alone. The reserpine-hy

Sanguinarine is a polycyclic quaternary alkaloid. It is extracted from some plants, including the bloodroot plant (Sanguinaria canadensis, from whose scientific name its name is derived), the Mexican prickly poppy (Argemone mexicana), Chelidonium majus, and Macleaya cordata.

Palmatine is a protoberberine alkaloid found in several plants including Coptis chinensis (Rhizoma coptidis, chinese goldthread), Corydalis yanhusuo, Tinospora cordifolia (gurjo, heart-leaved moonseed), Tinospora sagittata, Phellodendron amurense (amur cork tree), and Stephania yunnanensis.

Coptisine is an alkaloid found in Chinese goldthread (Coptis chinensis), greater celandine, and opium. Famous for the bitter taste that it produces, it is used in Chinese herbal medicine along with the related compound berberine for digestive disorders caused by bacterial infections.

Veracevine is an alkaloid that occurs in the seeds of Schoenocaulon officinale. It is used as an insecticide in veterinary medicine.

Rescinnamine, known by the brand names Moderil, Cinnasil, and Anaprel, is an angiotensin-converting enzyme inhibitor used as an antihypertensive drug.

Jatrorrhizine is a protoberberine alkaloid found in some plant species, such as Enantia chlorantha (Annonaceae). Synonyms that may be encountered include jateorrhizine, neprotin, jatrochizine, jatrorhizine, and yatrorizine.

Eletefine is an isoquinoline alkaloid first isolated in 1998 from Cissampelos glaberrima. It is one of few known compounds containing the so-called stephaoxocane skeleton, alongside stephaoxocanidine, excentricine, and the stephalonganines.

class of chemical compounds; any alkaloid that has a structure based on an isoquinoline nucleus

Nitidine is a benzophenanthridine alkaloid found in species of the genus Zanthoxylum , notably in Zanthoxylum nitidum. This compound has an anti-malarial activity.