Jatrorrhizine is a protoberberine alkaloid found in some plant species, such as Enantia chlorantha (Annonaceae). Synonyms that may be encountered include jateorrhizine, neprotin, jatrochizine, jatrorhizine, and yatrorizine.
Jatrorrhizine is a protoberberine alkaloid found in some plant species, such as Enantia chlorantha (Annonaceae). Synonyms that may be encountered include jateorrhizine, neprotin, jatrochizine, jatrorhizine, and yatrorizine.
== Bioactive effects == Jatrorrhizine has been reported to have antiinflammatory effect, and to improve blood flow and mitotic activity in thioacetamide-traumatized rat livers. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits monoamine oxidase (IC50 = 4 μM for MAO-A and 62 μM for MAO-B) It interferes with multidrug resistance by cancer cells in vitro when exposed to a chemotherapeutic agent. Large doses (50–100 mg/kg) reduced blood sugar levels in mice by increasing aerobic glycolysis.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).