Leukemia

Leukemia (also spelled leukaemia; pronounced ) is a group of blood cancers that usually begin in the bone marrow and produce high numbers of abnormal blood cells. These blood cells are not fully developed and are called blasts or leukemia cells. Symptoms may include bleeding and bruising, bone pain, fatigue, fever, and an increased risk of infections. These symptoms occur due to a lack of normal blood cells. Diagnosis is typically made by blood tests or bone marrow biopsy.

artificial T-cell receptor for use in immunotherapy

human disease

mammalian protein found in Homo sapiens

large, crystalline cytoplasmic inclusion bodies sometimes observed in myeloid blast cells

French biologist and physician (1801–1878)

Polish-American virologist

neoplasm of prolymphocytes affecting the blood, bone marrow, and spleen.

broad type of leukemia; disjoint with acute leukemia

medical condition

leukemia that occurs in children

leukemia that is located in myeloid tissue

Human disease

Leukostasis (also called symptomatic hyperleukocytosis) is a medical emergency most commonly seen in patients with acute myeloid leukemia. It is characterized by an extremely elevated blast cell count and symptoms of decreased tissue perfusion. The pathophysiology of leukostasis is not well understood, but inadequate delivery of oxygen to the body's cells is the result. Leukostasis is diagnosed when white cell plugs are seen in the microvasculature. The most common symptoms are dyspnea and hypoxia, usually accompanied by visual changes, headaches, dizziness, confusion, somnolence, and coma. Pr