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1-methylpseudouridine
Sign in to saveAlso known as m(1)f, N1-methylpseudouridine, m1Ψ
N1-Methylpseudouridine (abbreviated m1Ψ) is a natural archaeal tRNA component, and "hypermodified" pyrimidine nucleoside used in biochemistry and molecular biology for in vitro transcription and is found in the SARS-CoV-2 mRNA vaccines tozinameran (Pfizer–BioNTech) and elasomeran (Moderna).
Chemical data
- Formula
- C10H14N2O6
- Molecular weight
- 258.23 g/mol
- IUPAC name
- 5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-methylpyrimidine-2,4-dione
- SMILES
- CN1C=C(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
- InChIKey
- UVBYMVOUBXYSFV-XUTVFYLZSA-N
- XLogP
- -2.6
- Polar surface area
- 119 Ų
- H-bond donors
- 4
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Wikidata facts
- Mass
- 258.085186
Show 4 more facts
- chemical formula
- C₁₀H₁₄N₂O₆
- canonical SMILES
- CN1C=C(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
- isomeric SMILES
- CN1C=C(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
- Commons category
- N1-Methylpseudouridine
Sources (2)
via Wikidata · CC0
~3 min read
Encyclopedic overview
3 sectionsContents
- Properties
- History
- References
N1-Methylpseudouridine (abbreviated m1Ψ) is a natural archaeal tRNA component, and "hypermodified" pyrimidine nucleoside used in biochemistry and molecular biology for in vitro transcription and is found in the SARS-CoV-2 mRNA vaccines tozinameran (Pfizer–BioNTech) and elasomeran (Moderna).
== Properties ==
Excerpted from Wikipedia’s “1-methylpseudouridine” article, available under the CC BY-SA 4.0 licence.