12-crown-4

Also known as 12-crown-4 ether, EOCT, ethylene oxide cyclic tetramer, 1,4,7,10-tetraoxacyclododecane

12-Crown-4, also called 1,4,7,10-tetraoxacyclododecane and lithium ionophore V, is a crown ether with the formula C8H16O4. It is a cyclic tetramer of ethylene oxide which is specific for the lithium cation.

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Encyclopedic overview

4 sections

Contents

Synthesis
Properties
References
See also

== Synthesis == 12-Crown-4 can be synthesized using a modified Williamson ether synthesis, using LiClO4 as a templating cation: (CH2OCH2CH2Cl)2 + (CH2OH)2 + 2 NaOH → (CH2CH2O)4 + 2 NaCl + 2 H2O

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