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I can only provide that "1749" was a year in the 18th century, but without additional context about what specific events, works, or subjects you're interested in, I cannot explain what makes it significant or why it would matter to general readers. To write an accurate overview, I would need more information about what aspect of 1749 you'd like me to address.
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Article
April 27: First performance of George Frideric Handel's Music for the Royal Fireworks takes place.
1749 (MDCCXLIX) was a common year starting on Wednesday of the Gregorian calendar and a common year starting on Sunday of the Julian calendar, the 1749th year of the Common Era (CE) and Anno Domini (AD) designations, the 749th year of the 2nd millennium, the 49th year of the 18th century, and the 10th and last year of the 1740s decade. As of the start of 1749, the Gregorian calendar was 11 days ahead of the Julian calendar, which remained in localized use until 1923.