Structure via PubChem · Public domain (PubChem)
abiraterone
Sign in to saveAlso known as CB 7598, (3beta)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol, (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol, 17-(3-pyridyl)androsta-5,16-dien-3beta-ol
REDIRECT Abiraterone acetate
Chemical data
- Formula
- C24H31NO
- Molecular weight
- 349.5 g/mol
- IUPAC name
- (3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol
- SMILES
- C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4C5=CN=CC=C5)C)O
- InChIKey
- GZOSMCIZMLWJML-VJLLXTKPSA-N
- XLogP
- 4.6
- Polar surface area
- 33.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- neoplasm, prostate carcinoma, prostate adenocarcinoma, metastatic prostate cancer
via ChEMBL · EBI
Research
4,108 papers- Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design.Lancet (London, England) · 2022
- Olaparib plus abiraterone versus placebo plus abiraterone in metastatic castration-resistant prostate cancer (PROpel): final prespecified overall survival results of a randomised, double-blind, phase 3 trial.The Lancet. Oncology · 2023
- Abiraterone and Olaparib for Metastatic Castration-Resistant Prostate Cancer.NEJM evidence · 2022
- Capivasertib plus abiraterone in PTEN-deficient metastatic hormone-sensitive prostate cancer: CAPItello-281 phase III study.Annals of oncology : official journal of the European Society for Medical Oncology · 2026
- AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer.The New England journal of medicine · 2014
via PubMed
Wikidata facts
- Mass
- 349.241
- Has use
- medication
Show 8 more facts
- chemical formula
- C₂₄H₃₁NO
- canonical SMILES
- CC12CCC(CC1=CCC3C2CCC4(C3CC=C4C5=CN=CC=C5)C)O
- defined daily dose
- 1
- Commons category
- Abiraterone
- isomeric SMILES
- C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4C5=CN=CC=C5)C)O
- World Health Organisation international non-proprietary name
- abiraterone
- physically interacts with
- cytochrome P450 family 17 subfamily A member 1
- subject has role
- 5-alpha-reductase inhibitors
via Wikidata · CC0
~1 min read
Encyclopedic overview
REDIRECT Abiraterone acetate
Excerpted from Wikipedia’s “abiraterone” article, available under the CC BY-SA 4.0 licence.