Gene data
ACP2- Name
- acid phosphatase 2, lysosomal
- Type
- protein-coding
- Position
- 47,237,598–47,249,288 (−)
- Aliases
- LAP
- Ensembl
- ENSG00000134575
- RefSeq RNA
- NM_001131064.1, NM_001302489.2, NM_001302490.2, NM_001302491.2, NM_001302492.2
- RefSeq protein
- NP_001289418.1, NP_001289419.1, NP_001289420.1, NP_001289421.1, NP_001343945.1
The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
acid phosphatase 2, lysosomal
- Symbol
- ACP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:47,237,598-47,249,288
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 1217
- exact match
- identifiers.org/ncbigene/53
- found in taxon
- Homo sapiens
- genomic end
- 47248906
- genomic start
- 47239302
- chromosome
- human chromosome 11
- cytogenetic location
- 11p11.2|11p12-p11
- expressed in
- salivary gland
Sources (3)
via Wikidata · CC0