ACTR2

Also known as ARP2, ARP2 actin-related protein 2 homolog (yeast), ARP2 actin related protein 2 homolog, actin related protein 2, Actin related protein 2/3 complex subunit 2, p34-ARC, ARPC2, arp2/3 complex 34 kDa subunit

Actin-related protein 2/3 complex subunit 2 is a protein that in humans is encoded by the ARPC2 gene.

In the Vinony graph

Vinony's link graph records 4 inbound references to ACTR2, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 2.

Vinony links it to 6 Wikipedia language editions.

Gene data

ACTR2

Name: actin related protein 2
Type: protein-coding
Position: 65,227,714–65,271,253 (+)
Aliases: ARP2
Ensembl: ENSG00000138071
RefSeq RNA: NM_001005386.3, NM_005722.4
RefSeq protein: NP_001005386.1, NP_005713.1

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

positive regulation of lamellipodium assembly Arp2/3 complex-mediated actin nucleation Arp2/3 complex-mediated actin nucleation positive regulation of transcription by RNA polymerase II cilium assembly positive regulation of double-strand break repair via homologous recombination regulation of double-strand break repair via nonhomologous end joining

Molecular function

structural constituent of cytoskeleton protein binding actin filament binding actin filament binding

Cellular component

extracellular region nucleus nucleus nucleolus cytoplasm cytosol cytoskeleton Arp2/3 protein complex

Pathways

Endocytosis - Homo sapiens (human)Tight junction - Homo sapiens (human)Fc gamma R-mediated phagocytosis - Homo sapiens (human)Regulation of actin cytoskeleton - Homo sapiens (human)Bacterial invasion of epithelial cells - Homo sapiens (human)Pathogenic Escherichia coli infection - Homo sapiens (human)Shigellosis - Homo sapiens (human)Salmonella infection - Homo sapiens (human)Yersinia infection - Homo sapiens (human)Developmental Biology

via MyGene.info

Gene · Ensembl

actin related protein 2

Symbol: ACTR2
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:65,227,714-65,271,253
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Protein · UniProt

Actin-related protein 2/3 complex subunit 2

Gene: ARPC2
Organism: Homo sapiens (Human)
Length: 300 aa
Molecular mass: 34,333 Da
Evidence: 1: Evidence at protein level

Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Ar…

3D-structureAcetylationActin-bindingCell projectionCytoplasmCytoskeletonDirect protein sequencingNucleus

View on UniProt →

Swiss-Prot (reviewed) · via UniProt