ADD1

Also known as ADDA, adducin 1

Alpha-adducin is a protein that in humans is encoded by the ADD1 gene.

Gene data

ADD1

Name: adducin 1
Type: protein-coding
Position: 2,843,576–2,930,082 (+)
Aliases: ADDA
Ensembl: ENSG00000087274
RefSeq RNA: NM_001119.5, NM_001286645.2, NM_001354754.2, NM_001354755.2, NM_001354756.2
RefSeq protein: NP_001110.2, NP_001273574.1, NP_001341683.1, NP_001341684.1, NP_001341685.1

Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017].

Pathways

Apoptosis Apoptotic cleavage of cellular proteins Cellular responses to stress Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes IRE1alpha activates chaperones Unfolded Protein Response (UPR)Transport of small molecules Miscellaneous transport and binding events Programmed Cell Death

via MyGene.info

Wikidata facts

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cytogenetic location: 4p16.3
genomic end: 2930076
genomic start: 2843844
HomoloGene ID: 22758
exact match: identifiers.org/ncbigene/118

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Alpha-adducin is a protein that in humans is encoded by the ADD1 gene.

Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. Polymorphism in ADD1 is associated with hypertension.