ADD1

Also known as ADDA, adducin 1

Alpha-adducin is a protein that in humans is encoded by the ADD1 gene.

Gene data

ADD1

Name: adducin 1
Type: protein-coding
Position: 2,843,576–2,930,082 (+)
Aliases: ADDA
Ensembl: ENSG00000087274
RefSeq RNA: NM_001119.5, NM_001286645.2, NM_001354754.2, NM_001354755.2, NM_001354756.2
RefSeq protein: NP_001110.2, NP_001273574.1, NP_001341683.1, NP_001341684.1, NP_001341685.1

Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017].

Pathways

Apoptosis Apoptotic cleavage of cellular proteins Cellular responses to stress Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes IRE1alpha activates chaperones Unfolded Protein Response (UPR)Transport of small molecules Miscellaneous transport and binding events Programmed Cell Death

via MyGene.info

Gene · Ensembl

adducin 1

Symbol: ADD1
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:2,843,576-2,930,082
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

cytogenetic location: 4p16.3
genomic end: 2930076
genomic start: 2843844
chromosome: human chromosome 4
HomoloGene ID: 22758
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/118

Sources (3)

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Encyclopedic overview

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References
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Further reading

Alpha-adducin is a protein that in humans is encoded by the ADD1 gene.

Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. Polymorphism in ADD1 is associated with hypertension.

Excerpted from Wikipedia’s “ADD1” article, available under the CC BY-SA 4.0 licence.